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    nas-8 Zinc metalloproteinase nas-8 [ Caenorhabditis elegans ]

    Gene ID: 183207, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nas-8
    Official Full Name
    Zinc metalloproteinase nas-8
    Primary source
    WormBase:WBGene00003527
    Locus tag
    CELE_C34D4.9
    See related
    AllianceGenome:WB:WBGene00003527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human ASTL (astacin like metalloendopeptidase); MEP1A (meprin A subunit alpha); and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nas-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (7114899..7119926)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BAR domain-containing protein Neighboring gene Sperm-Specific family, class Q Neighboring gene CHASE2 domain-containing protein Neighboring gene Seven TM Receptor Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc metalloproteinase nas-8
    NP_501114.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7114899..7119926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068713.7 → NP_501114.2  Zinc metalloproteinase nas-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501114.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18439, Q7Z0N4
      Conserved Domains (3) summary
      cd04280
      Location:123 → 304
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:119 → 308
      Astacin; Astacin (Peptidase family M12A)
      pfam01549
      Location:337 → 372
      ShK; ShK domain-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18439.3

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