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    rike-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rike-1
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00008266
    Locus tag
    CELE_C53A5.6
    See related
    AllianceGenome:WB:WBGene00008266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rike-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (14542905..14545866, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Calmodulin-binding domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene Serpentine receptor class gamma-47

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteotoxic stress disrupts epithelial integrity by inducing MTOR sequestration and autophagy overactivation. Cheng X, et al. Autophagy, 2023 Jan. PMID 35521960, Free PMC Article
    2. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923
    3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_001256597.1
    • Partially confirmed by transcript evidence
    NP_001379205.1
    • Confirmed by transcript evidence
    NP_001407539.1
    • Partially confirmed by transcript evidence
    NP_001407540.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14542905..14545866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392657.1 → NP_001379205.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17698
      Conserved Domains (5) summary
      PHA03098
      Location:333 → 559
      PHA03098; kelch-like protein; Provisional
      COG5432
      Location:9 → 137
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      sd00038
      Location:368 → 410
      Kelch; KELCH repeat [structural motif]
      cd00162
      Location:9 → 45
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      pfam14634
      Location:8 → 50
      zf-RING_5; zinc-RING finger domain

    2. NM_001420564.1 → NP_001407539.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9J5I4G4

    3. NM_001269668.4 → NP_001256597.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCU1
      Conserved Domains (4) summary
      PHA03098
      Location:336 → 562
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:371 → 413
      Kelch; KELCH repeat [structural motif]
      cd00162
      Location:9 → 45
      RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
      pfam14634
      Location:8 → 50
      zf-RING_5; zinc-RING finger domain

    4. NM_001420565.1 → NP_001407540.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9J5DGE9
    Nucleotide Protein
    Heading Accession and Version

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