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    lipl-2 Lipase [ Caenorhabditis elegans ]

    Gene ID: 185840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lipl-2
    Official Full Name
    Lipase
    Primary source
    WormBase:WBGene00009773
    Locus tag
    CELE_F46B6.8
    See related
    AllianceGenome:WB:WBGene00009773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lipl-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (9791567..9793241)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Zinc finger protein ztf-7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, et al. PLoS Biol, 2019 May. PMID 31086360, Free PMC Article
    2. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Buis A, et al. Cell Rep, 2019 Jul 23. PMID 31340142, Free PMC Article
    3. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. O'Rourke EJ, et al. Nat Cell Biol, 2013 Jun. PMID 23604316, Free PMC Article
    4. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article
    5. Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains. Gao AW, et al. iScience, 2022 Feb 18. PMID 35118355, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lipase
    NP_505527.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9791567..9793241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073126.4 → NP_505527.1  Lipase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20449
      Conserved Domains (2) summary
      PLN02872
      Location:4 → 401
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:35 → 98
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    Nucleotide Protein
    Heading Accession and Version

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