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    Pex11a peroxisomal biogenesis factor 11 alpha [ Mus musculus (house mouse) ]

    Gene ID: 18631, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pex11aprovided by MGI
    Official Full Name
    peroxisomal biogenesis factor 11 alphaprovided by MGI
    Primary source
    MGI:MGI:1338788
    See related
    Ensembl:ENSMUSG00000030545 AllianceGenome:MGI:1338788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEX11alpha
    Summary
    Predicted to enable protein homodimerization activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.5), liver adult (RPKM 10.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pex11a in Genome Data Viewer
    Location:
    7 45.12 cM; 7 D2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79385705..79392879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79735957..79743131, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene uncharacterized LOC118567517 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene perilipin 1 Neighboring gene WD repeat domain 93 Neighboring gene predicted gene 44705

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. Weng H, et al. Am J Physiol Endocrinol Metab, 2013 Jan 15. PMID 23169785
    2. Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions. Weng H, et al. Hypertension, 2014 Nov. PMID 25113963
    3. PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. Li X, et al. Mol Cell Biol, 2002 Dec. PMID 12417726, Free PMC Article
    4. Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. Schrader M, et al. J Biol Chem, 1998 Nov 6. PMID 9792670
    5. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Wu Y, et al. Am J Physiol Endocrinol Metab, 2008 Jul. PMID 18492766, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions.
      Title: Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions.
    2. Pex11alpha deficiency impairs peroxisome elongation and abundance and peroxisomal fatty acid oxidation, which contributes to increased lipid accumulation in the liver.
      Title: Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice.
    3. required for peroxisome proliferation in response to 4-phenylbutyrate but dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation
      Title: PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome membrane biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of peroxisome size IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of peroxisome size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 11A
    Names
    PEX11-alpha
    peroxin-11A
    peroxisomal biogenesis factor 11a
    protein PEX11 homolog alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011068.2 → NP_035198.1  peroxisomal membrane protein 11A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AK076776, AK149387
      Consensus CDS
      CCDS21386.1
      UniProtKB/Swiss-Prot
      Q8C5B8, Q9Z211
      UniProtKB/TrEMBL
      Q3UER4
      Related
      ENSMUSP00000032761.8, ENSMUST00000032761.8
      Conserved Domains (1) summary
      pfam05648
      Location:1 → 237
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    RNA

    1. NR_153403.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK076776, AK078954

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79385705..79392879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152777.1 → XP_036008670.1  peroxisomal membrane protein 11A isoform X1

      Conserved Domains (1) summary
      pfam05648
      Location:1 → 212
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z211.1 GenPept UniProtKB/Swiss-Prot:Q9Z211

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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