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    cnk-1 Connector enhancer of kinase suppressor of ras [ Caenorhabditis elegans ]

    Gene ID: 187518, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cnk-1
    Official Full Name
    Connector enhancer of kinase suppressor of ras
    Primary source
    WormBase:WBGene00000564
    Locus tag
    CELE_R01H10.8
    See related
    AllianceGenome:WB:WBGene00000564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to several human genes including CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cnk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (10271257..10278579)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner Neighboring gene BBSome complex member bbs-5 Neighboring gene PH domain-containing protein Neighboring gene GDP-fucose protein O-fucosyltransferase 2 Neighboring gene Bestrophin homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Clapéron A, et al. Oncogene, 2007 May 14. PMID 17496912
    2. Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Rocheleau CE, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16085714, Free PMC Article
    3. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
    4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    5. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
      Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
    2. CNK promotes Raf phosphorylation/activation through membrane localization
      Title: Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Connector enhancer of kinase suppressor of ras
    NP_001391083.1
    • Partially confirmed by transcript evidence
    NP_499274.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10271257..10278579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066873.7 → NP_499274.3  Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499274.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEW9
      Conserved Domains (6) summary
      smart00454
      Location:53 → 119
      SAM; Sterile alpha motif
      cd00992
      Location:267 → 337
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00169
      Location:636 → 736
      PH; PH domain
      pfam10534
      Location:129 → 219
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      cl15755
      Location:53 → 118
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:636 → 731
      PH-like; Pleckstrin homology-like domain

    2. NM_001404166.1 → NP_001391083.1  Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I9L4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEW9.1

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