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    icpp-55 Aminopeptidase P N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icpp-55
    Official Full Name
    Aminopeptidase P N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00020088
    Locus tag
    CELE_R119.2
    See related
    AllianceGenome:WB:WBGene00020088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See icpp-55 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (368270..373465, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene pseudo Neighboring gene RRM domain-containing protein Neighboring gene DeHydrogenases, Short chain Neighboring gene Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59 Neighboring gene Transcription initiation factor TFIID subunit 4 Neighboring gene Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aminopeptidase P N-terminal domain-containing protein
    NP_001417605.1
    • Confirmed by transcript evidence
    NP_490725.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      368270..373465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058324.5 → NP_490725.3  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490725.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61710
      Conserved Domains (2) summary
      pfam05195
      Location:20 → 149
      AMP_N; Aminopeptidase P, N-terminal domain
      cl00279
      Location:188 → 427
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    2. NM_001430679.1 → NP_001417605.1  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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