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    cdkl-1 Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdkl-1
    Official Full Name
    Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00012779
    Locus tag
    CELE_Y42A5A.4
    See related
    AllianceGenome:WB:WBGene00012779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in non-motile cilium assembly and regulation of cilium assembly. Located in ciliary transition zone. Is expressed in amphid neurons and phasmid neurons. Orthologous to several human genes including CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdkl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (11098899..11107343)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aminopeptidase Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene LYR motif-containing protein 5 Neighboring gene pseudo Neighboring gene Eukaryotic peptide chain release factor GTP-binding subunit;GTP-eEF1A C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DYF-5 RCK and CDKL-1 CDKL5 kinases contribute differentially to shape distinct sensory neuron cilia morphologies in C. elegans. Maurya AK, et al. MicroPubl Biol, 2022. PMID 35996689, Free PMC Article
    2. CDKL kinase regulates the length of the ciliary proximal segment. Park K, et al. Curr Biol, 2021 Jun 7. PMID 33857430
    3. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Canning P, et al. Cell Rep, 2018 Jan 23. PMID 29420175, Free PMC Article
    4. The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate. Gonçalves J, et al. Mol Cells, 2017 Apr. PMID 28401750, Free PMC Article
    5. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein
    NP_001256289.1
    • Confirmed by transcript evidence
    NP_001256290.1
    • Confirmed by transcript evidence
    NP_001256291.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11098899..11107343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269360.4 → NP_001256289.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZ10
      Conserved Domains (1) summary
      cd07847
      Location:133 → 417
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. NM_001269361.3 → NP_001256290.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZ11
      Conserved Domains (1) summary
      cd07847
      Location:32 → 316
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    3. NM_001269362.2 → NP_001256291.1  Cyclin-dependent kinase-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2H1
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2H1.1

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