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    bre-4 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [ Caenorhabditis elegans ]

    Gene ID: 190668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bre-4
    Official Full Name
    Beta-1,4-N-acetylgalactosaminyltransferase bre-4
    Primary source
    WormBase:WBGene00000269
    Locus tag
    CELE_Y73E7A.7
    See related
    AllianceGenome:WB:WBGene00000269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in positive regulation of Notch signaling pathway; protein glycosylation; and response to toxic substance. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to several human genes including B4GALT1 (beta-1,4-galactosyltransferase 1) and B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bre-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (1621314..1628486, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein BFR2 Neighboring gene Bladder cancer-associated protein Neighboring gene WD and tetratricopeptide repeats protein 1;WD_REPEATS_REGION domain-containing protein Neighboring gene Coiled-coil domain-containing protein Neighboring gene Mucin-5AC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. Kawar ZS, et al. J Biol Chem, 2002 Sep 20. PMID 12167666
    2. Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans. Kremer J, et al. Gerontology, 2020. PMID 33171474
    3. Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity. Wohlschlager T, et al. J Biol Chem, 2011 Sep 2. PMID 21757752, Free PMC Article
    4. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Barrows BD, et al. J Biol Chem, 2007 Feb 2. PMID 17135259
    5. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Marroquin LD, et al. Genetics, 2000 Aug. PMID 10924467, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-1,4-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,4-N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Beta-1,4-N-acetylgalactosaminyltransferase bre-4
    NP_001370927.1
    • Confirmed by transcript evidence
    NP_490872.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1621314..1628486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058471.2 → NP_490872.1  Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490872.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GUM2, W6SB74
      Conserved Domains (1) summary
      cd00899
      Location:147 → 365
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. NM_001383737.2 → NP_001370927.1  Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd00899
      Location:1 → 200
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GUM2.1

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