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    gcy-36 Soluble guanylate cyclase gcy-36 [ Caenorhabditis elegans ]

    Gene ID: 191657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-36
    Official Full Name
    Soluble guanylate cyclase gcy-36
    Primary source
    WormBase:WBGene00001556
    Locus tag
    CELE_C46E1.2
    See related
    AllianceGenome:WB:WBGene00001556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables oxygen sensor activity. Involved in feeding behavior and response to oxygen levels. Located in dendrite and neuronal cell body. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to several human genes including GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-36 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (15479017..15485711)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene IRG-type G domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans. Mok CA, et al. PLoS Genet, 2011 Oct. PMID 22022287, Free PMC Article
    2. Regulation of Neuronal Oxygen Responses in C. elegans Is Mediated through Interactions between Globin 5 and the H-NOX Domains of Soluble Guanylate Cyclases. Abergel Z, et al. J Neurosci, 2016 Jan 20. PMID 26791224, Free PMC Article
    3. Experience-dependent modulation of C. elegans behavior by ambient oxygen. Cheung BH, et al. Curr Biol, 2005 May 24. PMID 15916947
    4. GCY-35/GCY-36-TAX-2/TAX-4 Signalling in O(2) Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans. Chen YH, et al. Sci Rep, 2018 Feb 14. PMID 29445226, Free PMC Article
    5. Can oxygen anosmia extend lifespan? Abergel R, et al. Aging (Albany NY), 2017 Nov 30. PMID 29190215, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants
      Title: Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feeding behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Soluble guanylate cyclase gcy-36
    NP_510557.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15479017..15485711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078156.8 → NP_510557.3  Soluble guanylate cyclase gcy-36 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510557.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6DNF4, Q9XTE0
      Conserved Domains (4) summary
      smart00044
      Location:415 → 604
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:441 → 624
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:3 → 167
      HNOB; Haem-NO-binding
      pfam07701
      Location:217 → 435
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DNF4.1

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