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    Rassf3 Ras association (RalGDS/AF-6) domain family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 192678, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rassf3provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 3provided by MGI
    Primary source
    MGI:MGI:2179722
    See related
    Ensembl:ENSMUSG00000025795 AllianceGenome:MGI:2179722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in embryo mesenchyme and tongue. Orthologous to human RASSF3 (Ras association domain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 43.3), lung adult (RPKM 33.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rassf3 in Genome Data Viewer
    Location:
    10 D2; 10 69.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121246255..121312220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121410350..121476250, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9808 Neighboring gene STARR-positive B cell enhancer ABC_E11462 Neighboring gene STARR-positive B cell enhancer ABC_E9809 Neighboring gene glucosamine (N-acetyl)-6-sulfatase Neighboring gene mitochondrial ribosomal protein S11 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5194 Neighboring gene predicted gene, 53638 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:120913883-120914036 Neighboring gene STARR-positive B cell enhancer ABC_E5195 Neighboring gene predicted gene, 40787 Neighboring gene STARR-positive B cell enhancer ABC_E11463 Neighboring gene predicted gene, 46204

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Tommasi S, et al. Oncogene, 2002 Apr 18. PMID 11965544
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 3
    Names
    Ras association (RalGDS/AF-6) domain family 3
    Ras association domain family 3
    novel ras effector 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418941.1 → NP_001405870.1  ras association domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140264

    2. NM_138956.4 → NP_620406.1  ras association domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140264
      Consensus CDS
      CCDS24211.1
      UniProtKB/Swiss-Prot
      Q3TJ17, Q99P51
      Related
      ENSMUSP00000026902.8, ENSMUST00000026902.9
      Conserved Domains (2) summary
      cd01778
      Location:78 → 182
      RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
      pfam16517
      Location:186 → 225
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      121246255..121312220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243388.1 → XP_011241690.1  ras association domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      pfam16517
      Location:173 → 212
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl28922
      Location:37 → 166
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P51.1 GenPept UniProtKB/Swiss-Prot:Q99P51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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