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    Sftpc surfactant associated protein C [ Mus musculus (house mouse) ]

    Gene ID: 20389, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sftpcprovided by MGI
    Official Full Name
    surfactant associated protein Cprovided by MGI
    Primary source
    MGI:MGI:109517
    See related
    Ensembl:ENSMUSG00000022097 AllianceGenome:MGI:109517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP5; SPC; SP-C; Sftp2; Bricd6; Sftp-2; pro-SpC
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in respiratory gaseous exchange by respiratory system. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung; lung surfactant; and main bronchus epithelium. Used to study desquamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward lung adult (RPKM 8709.5) See more
    Orthologs
    human all
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    Genomic context

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    See Sftpc in Genome Data Viewer
    Location:
    14 D2; 14 36.32 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70758381..70761521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70520941..70524081, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E7332 Neighboring gene bone morphogenetic protein 1 Neighboring gene predicted gene, 52136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70920317-70920426 Neighboring gene leucine-rich repeat LGI family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E7333 Neighboring gene receptor accessory protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SFTPC mutations cause SP-C degradation and aggregate formation without increasing ER stress. Thurm T, et al. Eur J Clin Invest, 2013 Aug. PMID 23701443
    2. Embryonic stem cells form glandular structures and express surfactant protein C following culture with dissociated fetal respiratory tissue. Denham M, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Jun. PMID 16399789
    3. Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features. Rodriguez L, et al. Am J Respir Cell Mol Biol, 2023 Apr. PMID 36473455, Free PMC Article
    4. Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells. Lee JH, et al. Am J Respir Cell Mol Biol, 2013 Mar. PMID 23204392, Free PMC Article
    5. Transgenic glucocorticoid receptor expression driven by the SP-C promoter reduces neonatal lung cellularity and midkine expression in GRhypo mice. Gagnon S, et al. Biol Neonate, 2006. PMID 16534186

    See all (579) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Humanized L184Q Mutated Surfactant Protein C Gene Alters Alveolar Type 2 Epithelial Cell Fate.
      Title: Humanized L184Q Mutated Surfactant Protein C Gene Alters Alveolar Type 2 Epithelial Cell Fate.
    2. Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
      Title: Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
    3. Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.
      Title: Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.
    4. Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
      Title: Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
    5. Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice.
      Title: Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice.
    6. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.
      Title: Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.
    7. Role of CCR2(+) Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium.
      Title: Role of CCR2(+) Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium.
    8. An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
      Title: An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
    9. CRISPR Sftpc gene editing successfully treats lethal monogenic lung disease in utero in a mouse model.
      Title: CRISPR Gene Editing Successfully Treats Lethal Monogenic Lung Disease in Utero.
    10. Yap and Taz (Wwtr1) have roles in surfactant protein C-expressing (SPC-expressing) alveolar epithelial type II cells during alveolar epithelial regeneration and resolution of lung inflammation in response to bacterial pneumonia-induced lung injury
      Title: Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (15)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in alveolar lamellar body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    surfactant protein C
    Names
    pulmonary surfactant-associated protein C
    pulmonary surfactant-associated proteolipid SPL(Val)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011359.2 → NP_035489.2  surfactant protein C

      See identical proteins and their annotated locations for NP_035489.2

      Status: VALIDATED

      Source sequence(s)
      AC122268, BY773034, CJ093163, CJ237354
      Consensus CDS
      CCDS27254.1
      UniProtKB/Swiss-Prot
      P21841
      UniProtKB/TrEMBL
      Q6P8P8
      Related
      ENSMUSP00000022692.4, ENSMUST00000022692.5
      Conserved Domains (3) summary
      smart00019
      Location:1 → 193
      SF_P; Pulmonary surfactant proteins
      smart01039
      Location:94 → 193
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
      pfam08999
      Location:1 → 93
      SP_C-Propep; Surfactant protein C, N terminal propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70758381..70761521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21841.1 GenPept UniProtKB/Swiss-Prot:P21841

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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