Shc1 src homology 2 domain-containing transforming protein C1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shc1provided by MGI
Official Full Name: src homology 2 domain-containing transforming protein C1provided by MGI
Primary source: MGI:MGI:98296
See related: Ensembl:ENSMUSG00000042626 AllianceGenome:MGI:98296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Shc; p66; ShcA; p66shc
Summary: Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; epidermal growth factor receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cerebral cortex; early conceptus; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 33.0), ovary adult (RPKM 32.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.11 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89325858..89337336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89418551..89430029)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.
Title: p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.
Title: The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.
Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
Title: Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
[Study of senescence protein p66[Shc] on myocardial tissue repair in adult mice].
Title: [Study of senescence protein p66(Shc) on myocardial tissue repair in adult mice].
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.
Title: SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.
Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
Title: Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
Title: USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION.
Title: LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION.
ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation.
Title: ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation.
Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.
Title: Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.

Submit: New GeneRIF Correction See all GeneRIFs (150)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Shc1 (e-PCR), detects polymorphism
- UniSTS:532499

PMC316585P1 (e-PCR)
- UniSTS:273016

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables neurotrophin TRKA receptor binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin TRKA receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to endothelin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Shc-EGFR complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SHC-transforming protein 1

Names: SH2 domain protein C1; SHC-transforming protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113331.2 → NP_001106802.1 SHC-transforming protein 1 isoform a

See identical proteins and their annotated locations for NP_001106802.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK049357, BB458154, BB656759, BQ031241

Consensus CDS

CCDS50962.1

UniProtKB/Swiss-Prot

P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7

Related

ENSMUSP00000091940.4, ENSMUST00000094378.10

Conserved Domains (2) summary

cd09925
Location:476 → 578

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
NM_011368.5 → NP_035498.2 SHC-transforming protein 1 isoform b

See identical proteins and their annotated locations for NP_035498.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AK049357, BB458154, BQ031241, BY341731

Consensus CDS

CCDS17508.1

UniProtKB/Swiss-Prot

P98083

Related

ENSMUSP00000140336.2, ENSMUST00000191485.7

Conserved Domains (2) summary

cd09925
Location:366 → 468

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:36 → 207

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain