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    Sntb2 syntrophin, basic 2 [ Mus musculus (house mouse) ]

    Gene ID: 20650, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sntb2provided by MGI
    Official Full Name
    syntrophin, basic 2provided by MGI
    Primary source
    MGI:MGI:101771
    See related
    Ensembl:ENSMUSG00000041308 AllianceGenome:MGI:101771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNT3; SNTL; Snt2
    Summary
    Predicted to enable actin binding activity; calmodulin binding activity; and structural molecule activity. Located in synapse. Orthologous to human SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 9.9), testis adult (RPKM 7.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sntb2 in Genome Data Viewer
    Location:
    8 D3; 8 53.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107662372..107740864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106935740..107014232)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene UTP4 small subunit processome component Neighboring gene ribosomal protein L10, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22588 Neighboring gene STARR-seq mESC enhancer starr_22589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:109526496-109526679 Neighboring gene predicted gene, 22085 Neighboring gene STARR-positive B cell enhancer ABC_E3803 Neighboring gene predicted gene 16208 Neighboring gene vacuolar protein sorting 4A Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis. Rein-Fischboeck L, et al. Gene, 2023 Apr 5. PMID 36681100
    2. Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. Adams ME, et al. J Neurosci, 2004 Nov 17. PMID 15548643, Free PMC Article
    3. Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism. Riu E, et al. Biochem J, 2002 Dec 15. PMID 12230428, Free PMC Article
    4. Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Adams ME, et al. Neuron, 1993 Sep. PMID 7691103
    5. Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion. Abramovici H, et al. Cell Motil Cytoskeleton, 2007 Jul. PMID 17410543

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Current study shows that high SNTB2 in obese adipose tissues restricts adipocyte growth and thereby may contribute to metabolic diseases.
      Title: Adipocyte Hypertrophy and Improved Postprandial Lipid Response in Beta 2 Syntrophin Deficient Mice.
    2. Suggest alpha/beta2-syntrophins do not regulate ABCA1 activity and insulin release but may have a role in regulating glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism in obesity.
      Title: Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.
    3. ICA512-CCF also dimerizes with intact ICA512 on granules, thereby displacing it from beta2-syntrophin.
      Title: Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
    4. Results suggest DGK-zeta and syntrophins play a role at multiple stages of the fusion process.
      Title: Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-2-syntrophin
    Names
    59 kDa dystrophin-associated protein A1 basic component 2
    syntrophin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368316.1 → NP_001355245.1  beta-2-syntrophin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123864, AC123868
      Consensus CDS
      CCDS90456.1
      UniProtKB/TrEMBL
      B7ZNU9, Q3V2N5
      Related
      ENSMUSP00000037324.5, ENSMUST00000047425.5

    2. NM_009229.5 → NP_033255.1  beta-2-syntrophin isoform 2

      See identical proteins and their annotated locations for NP_033255.1

      Status: VALIDATED

      Source sequence(s)
      AC123864, AC123868
      Consensus CDS
      CCDS22642.1
      UniProtKB/Swiss-Prot
      Q61235
      UniProtKB/TrEMBL
      Q3V2N5, Q542S9
      Related
      ENSMUSP00000148684.2, ENSMUST00000212524.2
      Conserved Domains (4) summary
      smart00233
      Location:317 → 417
      PH; Pleckstrin homology domain
      cd00992
      Location:93 → 175
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01258
      Location:224 → 281
      PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
      pfam00169
      Location:306 → 417
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107662372..107740864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61235.2 GenPept UniProtKB/Swiss-Prot:Q61235

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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