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    Ankrd35 ankyrin repeat domain 35 [ Mus musculus (house mouse) ]

    Gene ID: 213121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd35provided by MGI
    Official Full Name
    ankyrin repeat domain 35provided by MGI
    Primary source
    MGI:MGI:2442590
    See related
    Ensembl:ENSMUSG00000038354 AllianceGenome:MGI:2442590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732436F15Rik
    Summary
    Is expressed in 2-cell stage embryo; 4-cell stage embryo; anterior naris; and external naris. Orthologous to human ANKRD35 (ankyrin repeat domain 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 2.9), cerebellum adult (RPKM 1.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd35 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96577447..96598350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96670131..96691034)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha 10 Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix hydrolase 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene predicted gene, 22581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
    2. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081139.1 → NP_001074608.1  ankyrin repeat domain-containing protein 35 isoform 1

      See identical proteins and their annotated locations for NP_001074608.1

      Status: VALIDATED

      Source sequence(s)
      AC112261
      Consensus CDS
      CCDS38558.1
      UniProtKB/TrEMBL
      A6H648, E9Q9D8
      Related
      ENSMUSP00000047244.6, ENSMUST00000048427.9
      Conserved Domains (4) summary
      cd00204
      Location:81 → 206
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:53 → 84
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:190 → 251
      Ank_2; Ankyrin repeats (3 copies)
      cl25732
      Location:710 → 996
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001356538.1 → NP_001343467.1  ankyrin repeat domain-containing protein 35 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC112261
      Consensus CDS
      CCDS38558.1
      UniProtKB/TrEMBL
      A6H648, E9Q9D8
      Conserved Domains (4) summary
      cd00204
      Location:81 → 206
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:53 → 84
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:190 → 251
      Ank_2; Ankyrin repeats (3 copies)
      cl25732
      Location:710 → 996
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001356539.1 → NP_001343468.1  ankyrin repeat domain-containing protein 35 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112261
      UniProtKB/TrEMBL
      B7ZNG5
      Conserved Domains (3) summary
      PHA02875
      Location:7 → 164
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:659 → 945
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:35 → 66
      ANK; ANK repeat [structural motif]

    4. NM_001356540.1 → NP_001343469.1  ankyrin repeat domain-containing protein 35 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112261, AK046624
      UniProtKB/TrEMBL
      B7ZNG5
      Conserved Domains (3) summary
      PHA02875
      Location:7 → 164
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:659 → 945
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:35 → 66
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96577447..96598350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319516.2 → XP_017175005.1  ankyrin repeat domain-containing protein 35 isoform X1

      UniProtKB/TrEMBL
      B7ZNG5
      Conserved Domains (3) summary
      PHA02875
      Location:7 → 164
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:659 → 945
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:35 → 66
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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