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    Nudt18 nudix hydrolase 18 [ Mus musculus (house mouse) ]

    Gene ID: 213484, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nudt18provided by MGI
    Official Full Name
    nudix hydrolase 18provided by MGI
    Primary source
    MGI:MGI:2385853
    See related
    Ensembl:ENSMUSG00000045211 AllianceGenome:MGI:2385853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable 8-hydroxy-dADP phosphatase activity; 8-oxo-GDP phosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Is expressed in several structures, including central nervous system; embryo endoderm; and retina. Orthologous to human NUDT18 (nudix hydrolase 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 56.4), subcutaneous fat pad adult (RPKM 9.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt18 in Genome Data Viewer
    Location:
    14 D2; 14 36.32 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70815264..70820128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70577824..70582688)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene lysine demethylase and nuclear receptor corepressor Neighboring gene STARR-positive B cell enhancer ABC_E8570 Neighboring gene predicted gene, 53866 Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70999253-70999362 Neighboring gene dematin actin binding protein Neighboring gene STARR-seq mESC enhancer starr_37085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38179

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 8-hydroxy-dADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-hydroxy-dADP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 8-oxo-GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-oxo-GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dADP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dGDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    8-oxo-dGDP phosphatase NUDT18
    Names
    2-hydroxy-dADP phosphatase
    7,8-dihydro-8-oxoguanine phosphatase
    mutT homolog 3
    nudix (nucleoside diphosphate linked moiety X)-type motif 18
    NP_001347403.1
    NP_001347404.1
    NP_694776.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360474.1 → NP_001347403.1  8-oxo-dGDP phosphatase NUDT18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122268, AK089446, AK157937
      Consensus CDS
      CCDS88705.1
      UniProtKB/TrEMBL
      A0A2I3BQN8
      Related
      ENSMUSP00000154258.2, ENSMUST00000228768.2
      Conserved Domains (1) summary
      cl00447
      Location:1 → 108
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. NM_001360475.1 → NP_001347404.1  8-oxo-dGDP phosphatase NUDT18 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122268, AK089446, AK157937
      Conserved Domains (1) summary
      cl00447
      Location:1 → 89
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    3. NM_153136.5 → NP_694776.2  8-oxo-dGDP phosphatase NUDT18 isoform 1

      See identical proteins and their annotated locations for NP_694776.2

      Status: VALIDATED

      Source sequence(s)
      AC122268, AK089446, AK157937
      Consensus CDS
      CCDS27258.1
      UniProtKB/Swiss-Prot
      Q3U2V3, Q8C223, Q8K1Y7
      Related
      ENSMUSP00000086450.3, ENSMUST00000089049.4
      Conserved Domains (1) summary
      cd04671
      Location:44 → 166
      Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70815264..70820128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2V3.1 GenPept UniProtKB/Swiss-Prot:Q3U2V3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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