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    Fbxo42 F-box protein 42 [ Mus musculus (house mouse) ]

    Gene ID: 213499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo42provided by MGI
    Official Full Name
    F-box protein 42provided by MGI
    Primary source
    MGI:MGI:1924992
    See related
    Ensembl:ENSMUSG00000028920 AllianceGenome:MGI:1924992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1332; 6720460I06Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; glossopharyngeal ganglion; spinal cord; trigeminal ganglion; and vestibulo-cochlear ganglion. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 8.6), whole brain E14.5 (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo42 in Genome Data Viewer
    Location:
    4 D3; 4 73.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140875216..140931373)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141147922..141204062)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 21 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_11890 Neighboring gene STARR-positive B cell enhancer ABC_E3533 Neighboring gene STARR-positive B cell enhancer ABC_E3534 Neighboring gene STARR-seq mESC enhancer starr_11892 Neighboring gene STARR-positive B cell enhancer ABC_E10273 Neighboring gene STARR-positive B cell enhancer ABC_E3535 Neighboring gene STARR-positive B cell enhancer ABC_E6249 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:140795314-140795615 Neighboring gene Rho guanine nucleotide exchange factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. Nath AK, et al. PLoS One, 2009. PMID 19156209, Free PMC Article
    2. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172518.3 → NP_766106.2  F-box only protein 42

      See identical proteins and their annotated locations for NP_766106.2

      Status: VALIDATED

      Source sequence(s)
      BC058667, BQ177305, BY161466
      Consensus CDS
      CCDS18866.1
      UniProtKB/Swiss-Prot
      A2A824, Q6PDJ6, Q8CE76, Q99KY2
      UniProtKB/TrEMBL
      Q3TDH0
      Related
      ENSMUSP00000030757.10, ENSMUST00000030757.10
      Conserved Domains (4) summary
      sd00038
      Location:119 → 168
      Kelch; KELCH repeat [structural motif]
      pfam00906
      Location:317 → 432
      Hepatitis_core; Hepatitis core antigen
      pfam12937
      Location:47 → 82
      F-box-like; F-box-like
      pfam13415
      Location:130 → 182
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140875216..140931373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538702.5 → XP_006538765.1  F-box only protein 42 isoform X1

      UniProtKB/TrEMBL
      Q3TDH0
      Conserved Domains (6) summary
      PLN02772
      Location:189 → 276
      PLN02772; guanylate kinase
      sd00038
      Location:135 → 190
      Kelch; KELCH repeat [structural motif]
      pfam00906
      Location:278 → 393
      Hepatitis_core; Hepatitis core antigen
      pfam12937
      Location:47 → 82
      F-box-like
      pfam13854
      Location:190 → 229
      Kelch_5; Kelch motif
      pfam13415
      Location:91 → 143
      Kelch_3; Galactose oxidase, central domain

    2. XM_006538703.5 → XP_006538766.1  F-box only protein 42 isoform X2

      UniProtKB/TrEMBL
      Q3TNG8, Q3UA61, Q3UBU7
      Conserved Domains (5) summary
      PLN02772
      Location:96 → 183
      PLN02772; guanylate kinase
      sd00038
      Location:42 → 97
      Kelch; KELCH repeat [structural motif]
      pfam00906
      Location:185 → 300
      Hepatitis_core; Hepatitis core antigen
      pfam13854
      Location:97 → 136
      Kelch_5; Kelch motif
      pfam13415
      Location:1 → 50
      Kelch_3; Galactose oxidase, central domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDJ6.1 GenPept UniProtKB/Swiss-Prot:Q6PDJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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