Tnc tenascin C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tncprovided by MGI
Official Full Name: tenascin Cprovided by MGI
Primary source: MGI:MGI:101922
See related: Ensembl:ENSMUSG00000028364 AllianceGenome:MGI:101922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik
Summary: Predicted to enable fibronectin binding activity; integrin binding activity; and syndecan binding activity. Involved in several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and regulation of inflammatory response. Acts upstream of or within positive regulation of cell population proliferation; positive regulation of gene expression; and prostate gland development. Located in basement membrane; extracellular region; and interstitial matrix. Part of tenascin complex. Is active in perisynaptic extracellular matrix. Is expressed in several structures, including alimentary system; brain; heart and pericardium; immune system; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 49.7), bladder adult (RPKM 28.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C1; 4 34.06 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63878022..63965554, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63959785..64047015, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal Tenascin-C primes macrophage pyroptosis amplifying aberrant inflammation during sepsis-induced acute lung injury.
Title: Exosomal Tenascin-C primes macrophage pyroptosis amplifying aberrant inflammation during sepsis-induced acute lung injury.
The Role of Tenascin-C on the Structural Plasticity of Perineuronal Nets and Synaptic Expression in the Hippocampus of Male Mice.
Title: The Role of Tenascin-C on the Structural Plasticity of Perineuronal Nets and Synaptic Expression in the Hippocampus of Male Mice.
Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
Title: Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
Role of tenascin C in lesion formation in early peritoneal endometriosis.
Title: Role of tenascin C in lesion formation in early peritoneal endometriosis.
Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.
Title: Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.
Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2.
Title: Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2.
TNC Accelerates Hypoxia-Induced Cardiac Injury in a METTL3-Dependent Manner.
Title: TNC Accelerates Hypoxia-Induced Cardiac Injury in a METTL3-Dependent Manner.
Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury.
Title: Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury.
The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
Title: The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Title: Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (123)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130033 (e-PCR)
- UniSTS:213321

AI528729 (e-PCR)
- UniSTS:179019

Tnc (e-PCR), detects polymorphism
- UniSTS:531314

Tnc (e-PCR), detects polymorphism
- UniSTS:497304

Tnc (e-PCR), detects polymorphism
- UniSTS:276147

Tnc (e-PCR), detects polymorphism
- UniSTS:276148

Tnc (e-PCR), detects polymorphism
- UniSTS:276149

Tnc (e-PCR), detects polymorphism
- UniSTS:276150

Tnc (e-PCR), detects polymorphism
- UniSTS:276151

Tnc (e-PCR), detects polymorphism
- UniSTS:276152

Tnc (e-PCR), detects polymorphism
- UniSTS:276153

Tnc (e-PCR), detects polymorphism
- UniSTS:276154

Tnc (e-PCR), detects polymorphism
- UniSTS:276155

Tnc (e-PCR), detects polymorphism
- UniSTS:276156

Tnc (e-PCR), detects polymorphism
- UniSTS:276157

Tnc (e-PCR), detects polymorphism
- UniSTS:276158

Tnc (e-PCR), detects polymorphism
- UniSTS:276159

Tnc (e-PCR), detects polymorphism
- UniSTS:276160

Tnc (e-PCR), detects polymorphism
- UniSTS:276161

Tnc (e-PCR), detects polymorphism
- UniSTS:276162

BB343343 (e-PCR)
- UniSTS:208636

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in bud outgrowth involved in lung branching	IEA Inferred from Electronic Annotation more info
involved_in bud outgrowth involved in lung branching	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to prostaglandin D stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vitamin D	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peripheral nervous system axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix of synaptic cleft	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in perisynaptic extracellular matrix	EXP Inferred from Experiment more info	PubMed
is_active_in perisynaptic extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perisynaptic extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
part_of tenascin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: tenascin

Names: hexabrachion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369211.1 → NP_001356140.1 tenascin isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL732556

Consensus CDS

CCDS89763.1

UniProtKB/Swiss-Prot

Q64706, Q80YX1, Q80YX2

Related

ENSMUSP00000102995.2, ENSMUST00000107372.8

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:1889 → 2098

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain
NM_001369212.1 → NP_001356141.1 tenascin isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL732556

UniProtKB/TrEMBL

Q148T4

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:1707 → 1916

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain
NM_001369213.1 → NP_001356142.1 tenascin isoform 4

Status: VALIDATED

Source sequence(s)

AL732556

Conserved Domains (4) summary

cd00063
Location:363 → 449

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:1537 → 1746

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:147 → 173

EGF_2; EGF-like domain

pfam00041
Location:633 → 715

fn3; Fibronectin type III domain
NM_001369214.1 → NP_001356143.1 tenascin isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL732556

UniProtKB/TrEMBL

Q148T4, Q148T5

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:1343 → 1552

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain
NM_011607.3 → NP_035737.2 tenascin isoform 2 precursor

See identical proteins and their annotated locations for NP_035737.2

Status: VALIDATED

Source sequence(s)

AK040167, AL732556, BC117979, BY300535, CN664449

Consensus CDS

CCDS18265.1

UniProtKB/Swiss-Prot

Q80YX1

UniProtKB/TrEMBL

Q148T5, Q8C9Z1

Related

ENSMUSP00000103000.4, ENSMUST00000107377.10

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1798 → 2007

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

63878022..63965554 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537776.2 → XP_006537839.1 tenascin isoform X1

UniProtKB/TrEMBL

Q148T4

Conserved Domains (6) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:1434 → 1643

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:345 → 372

EGF_2; EGF-like domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam01414
Location:516 → 558

DSL; Delta serrate ligand

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain