Slc17a9 solute carrier family 17, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc17a9provided by MGI
Official Full Name: solute carrier family 17, member 9provided by MGI
Primary source: MGI:MGI:1919107
See related: Ensembl:ENSMUSG00000023393 AllianceGenome:MGI:1919107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vnut; 1700019H03Rik
Summary: Enables purine nucleotide uniporter activity. Involved in purine nucleotide import into lysosome. Acts upstream of with a positive effect on ATP export. Acts upstream of or within lysosomal protein catabolic process. Located in chromaffin granule membrane. Is active in lysosomal membrane. Is expressed in esophagus; male reproductive gland or organ; and nasal cavity epithelium. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human SLC17A9 (solute carrier family 17 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 55.9), genital fat pad adult (RPKM 48.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.28 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180363989..180384073)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180724576..180742280)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Title: Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.
Title: VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.
Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.
Title: Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.
Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
Title: Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
expression of TRPV4 and VNUT in normal human gastrointestinal cell derived cell lines
Title: Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
Data (including data from studies using knockout mice) suggest that Vnut/Slc17a9 localized in tertiary/secretory granules of neutrophils is responsible for vesicular ATP release and subsequent neutrophil migration/infiltration.
Title: Vesicular nucleotide transporter mediates ATP release and migration in neutrophils.
FLX-induced anti-depressive behavior was decreased in astrocyte-selective VNUT-knockout mice or when VNUT was deleted in mice, but it was increased when astrocyte-selective VNUT was overexpressed in mice
Title: Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
VNUT is necessary for exocytotic ATP release from spinal dorsal horn neurons which contributes to neuropathic pain.
Title: Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.
This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9 and also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9
Title: Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force.
clock genes exist in the mouse bladder mucosa and regulate exact circadian gene expression in mice
Title: Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB413152 (e-PCR)
- UniSTS:207453

NoName (e-PCR)
- UniSTS:234626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables guanine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables purine nucleotide uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables purine nucleotide uniporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables purine nucleotide uniporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ADP transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_positive_effect ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ATP export	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_positive_effect ATP export	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ATP transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within guanine nucleotide transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within lysosomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleotide import into lysosome	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleotide import into lysosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromaffin granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chromaffin granule membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mucin granule	IEA Inferred from Electronic Annotation more info
is_active_in mucin granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated purine nucleotide uniporter SLC17A9

Names: vesicular nucleotide transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183161.3 → NP_898984.3 voltage-gated purine nucleotide uniporter SLC17A9

Status: VALIDATED

Source sequence(s)

AK006122, AW554829, BE850231, BG087579, CF165170

Consensus CDS

CCDS38378.1

UniProtKB/Swiss-Prot

A2AJ51, Q8VCL5

Related

ENSMUSP00000091771.4, ENSMUST00000094218.4

Conserved Domains (2) summary

cd06174
Location:40 → 432

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00893
Location:43 → 424

2A0114; D-galactonate transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180363989..180384073

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500591.3 → XP_006500654.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X2

Conserved Domains (1) summary

cl28910
Location:112 → 367

MFS; Major Facilitator Superfamily
XM_006500589.3 → XP_006500652.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X1

Conserved Domains (1) summary

cd17380
Location:42 → 377

MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters
XM_006500590.5 → XP_006500653.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X1

Conserved Domains (1) summary

cd17380
Location:42 → 377

MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters