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    Ipo7 importin 7 [ Mus musculus (house mouse) ]

    Gene ID: 233726, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ipo7provided by MGI
    Official Full Name
    importin 7provided by MGI
    Primary source
    MGI:MGI:2152414
    See related
    Ensembl:ENSMUSG00000066232 AllianceGenome:MGI:2152414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp7; Ranbp7; C330016G14; A330055O14Rik
    Summary
    Enables histone binding activity. Involved in negative regulation of osteoblast differentiation; positive regulation of odontoblast differentiation; and positive regulation of protein localization to nucleus. Acts upstream of or within innate immune response and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO7 (importin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 27.1), placenta adult (RPKM 21.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipo7 in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109617522..109655816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110018315..110056609)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:117129931-117130114 Neighboring gene RIKEN cDNA 1600010M07 gene Neighboring gene STARR-seq mESC enhancer starr_19812 Neighboring gene predicted gene, 23100 Neighboring gene predicted gene, 25636 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene zinc finger protein 143 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38. Ding N, et al. Inflamm Res, 2023 May. PMID 37004548, Free PMC Article
    2. Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice. Lee AY, et al. Anticancer Res, 2017 May. PMID 28476804
    3. Effects of transforming growth factor-β1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. Zhang Y, et al. Biochem Biophys Res Commun, 2021 Mar 19. PMID 33548622
    4. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. Saijou E, et al. J Biol Chem, 2007 Nov 2. PMID 17848547
    5. The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. She Y, et al. Cells Dev, 2022 Mar. PMID 34995814

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38.
      Title: Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38.
    2. IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.
      Title: IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.
    3. The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.
      Title: The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.
    4. Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.
      Title: Effects of transforming growth factor-β1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.
    5. Down-regulation of importin 7 suppresses lung tumorigenesis via suppressing Akt activity and inducing apoptosis
      Title: Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of odontoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin-7
    Names
    RAN binding protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362172.2 → NP_001349101.1  importin-7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC140235
      Conserved Domains (1) summary
      cl27876
      Location:15 → 996
      Cse1; Cse1

    2. NM_181517.5 → NP_852658.2  importin-7 isoform 1

      See identical proteins and their annotated locations for NP_852658.2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC140235
      Consensus CDS
      CCDS40085.1
      UniProtKB/Swiss-Prot
      Q7TN09, Q7TQ63, Q8BKD8, Q8BYI0, Q9EPL8
      Related
      ENSMUSP00000081782.4, ENSMUST00000084731.5
      Conserved Domains (2) summary
      COG5656
      Location:15 → 997
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03810
      Location:22 → 101
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109617522..109655816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPL8.2 GenPept UniProtKB/Swiss-Prot:Q9EPL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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