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    Zfp280d zinc finger protein 280D [ Mus musculus (house mouse) ]

    Gene ID: 235469, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp280dprovided by MGI
    Official Full Name
    zinc finger protein 280Dprovided by MGI
    Primary source
    MGI:MGI:2384583
    See related
    Ensembl:ENSMUSG00000038535 AllianceGenome:MGI:2384583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Suhw4; ZNF634; Znf280d; A930005F02Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in early conceptus; nervous system; olfactory epithelium; oocyte; and retina. Orthologous to human ZNF280D (zinc finger protein 280D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 9.8), CNS E14 (RPKM 9.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp280d in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72181900..72271061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72274618..72363779)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27188 Neighboring gene STARR-seq mESC enhancer starr_24588 Neighboring gene STARR-seq mESC enhancer starr_24589 Neighboring gene STARR-seq mESC enhancer starr_24590 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72123162-72123349 Neighboring gene predicted gene, 25163 Neighboring gene STARR-seq mESC enhancer starr_24593 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24594 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72238180-72238457 Neighboring gene predicted gene 27230 Neighboring gene cDNA sequence BC065403 Neighboring gene STARR-positive B cell enhancer mm9_chr9:72286185-72286486 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72297295-72297404 Neighboring gene STARR-positive B cell enhancer ABC_E5084 Neighboring gene meiosis-specific nuclear structural protein 1 Neighboring gene testis expressed gene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36902

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 280D
    Names
    suppressor of hairy wing homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311105.1 → NP_001298034.1  zinc finger protein 280D isoform 2

      See identical proteins and their annotated locations for NP_001298034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK045173, AK146597, BB616601, BC079878, CT025608
      Consensus CDS
      CCDS81035.1
      UniProtKB/TrEMBL
      Q3TEI2, V9GXP2
      Related
      ENSMUSP00000139250.2, ENSMUST00000183410.8
      Conserved Domains (2) summary
      sd00017
      Location:372 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57 → 241
      DUF4195; Domain of unknown function (DUF4195)

    2. NM_146224.5 → NP_666336.3  zinc finger protein 280D isoform 1

      See identical proteins and their annotated locations for NP_666336.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146597, BB616601, BC079878, CT025608
      Consensus CDS
      CCDS40683.1
      UniProtKB/Swiss-Prot
      Q3T9B1, Q68FE8, Q8BI82
      Related
      ENSMUSP00000096175.3, ENSMUST00000098576.10
      Conserved Domains (3) summary
      sd00017
      Location:372 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:335 → 369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57 → 241
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72181900..72271061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511121.4 → XP_006511184.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      Q3TEI2
      Conserved Domains (2) summary
      sd00017
      Location:372 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57 → 236
      DUF4195; Domain of unknown function (DUF4195)

    2. XM_006511122.3 → XP_006511185.1  zinc finger protein 280D isoform X3

      UniProtKB/TrEMBL
      Q3TEI2
      Related
      ENSMUSP00000138970.2, ENSMUST00000184517.8
      Conserved Domains (2) summary
      sd00017
      Location:372 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:57 → 236
      DUF4195; Domain of unknown function (DUF4195)

    3. XM_036154909.1 → XP_036010802.1  zinc finger protein 280D isoform X4

      Conserved Domains (1) summary
      sd00017
      Location:132 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017313342.2 → XP_017168831.1  zinc finger protein 280D isoform X1

      UniProtKB/TrEMBL
      V9GWW1
      Related
      ENSMUSP00000138857.2, ENSMUST00000184036.8
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 211
      DUF4195; Domain of unknown function (DUF4195)

    5. XM_017313343.2 → XP_017168832.1  zinc finger protein 280D isoform X5

      Conserved Domains (1) summary
      sd00017
      Location:102 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_030244338.1 → XP_030100198.1  zinc finger protein 280D isoform X4

      Conserved Domains (1) summary
      sd00017
      Location:132 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_004935419.1 RNA Sequence

    2. XR_004935420.1 RNA Sequence

    3. XR_004935421.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FE8.1 GenPept UniProtKB/Swiss-Prot:Q68FE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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