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    Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 [ Mus musculus (house mouse) ]

    Gene ID: 241612, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc5a12provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 12provided by MGI
    Primary source
    MGI:MGI:2138890
    See related
    Ensembl:ENSMUSG00000041644 AllianceGenome:MGI:2138890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMCT2; D630015G19
    Summary
    Enables lactate transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in apical plasma membrane and nucleoplasm. Is expressed in cortical early proximal tubule and renal proximal tubule. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 48.3) See more
    Orthologs
    human all
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    Genomic context

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    See Slc5a12 in Genome Data Viewer
    Location:
    2 E3; 2 56.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (110427644..110479690)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (110597299..110649345)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30319 Neighboring gene STARR-seq mESC enhancer starr_05369 Neighboring gene fin bud initiation factor homolog (zebrafish) Neighboring gene STARR-seq mESC enhancer starr_05370 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05371 Neighboring gene STARR-seq mESC enhancer starr_05372 Neighboring gene predicted gene, 52522 Neighboring gene anoctamin 3 Neighboring gene mucin 15 Neighboring gene STARR-seq mESC enhancer starr_05373 Neighboring gene POTE ankyrin domain family member 1 Neighboring gene RB1-inducible coiled-coil 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract. Teramae H, et al. Biomed Res, 2010 Aug. PMID 20834181
    2. Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring. Pucino V, et al. Cell Metab, 2019 Dec 3. PMID 31708446, Free PMC Article
    3. Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Srinivas SR, et al. Biochem J, 2005 Dec 15. PMID 16104846, Free PMC Article
    4. Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Martin PM, et al. Invest Ophthalmol Vis Sci, 2007 Jul. PMID 17591909
    5. Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine. Ohkubo M, et al. Drug Metab Pharmacokinet, 2012. PMID 22123132

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
      Title: Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
    2. A low affinity type of SMCT2-like transporter is in operation with high capacity throughout the small intestine, playing the role as the major intestinal nicotinate uptake transporter.
      Title: Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine.
    3. SMCT2 was localized in the brush border of enterocytes in the intestinal villi, and SMCT2 was localized in the brush border of is a jejunal type of SCMT.
      Title: The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract.
    4. low-affinity transporter SMCT2 initiates lactate absorption in the early parts of the proximal tubule followed by the participation of the high-affinity transporter SMCT1 in the latter parts of the proximal tubule.
      Title: Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.
    5. These data provide the first evidence for the expression of SMCT1 and SMCT2 in the retina and for the cell-type specific distribution of these transporters within the retina.
      Title: Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina.
    6. slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate
      Title: c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney.
    7. The cloning and characterization of slc5a12 (SMCT2) is reported.
      Title: Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monocarboxylate:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled monocarboxylate transporter 2
    Names
    electroneutral sodium monocarboxylate cotransporter
    low-affinity sodium-lactate cotransporter
    sodium solute cotransporter
    solute carrier family 5 member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003915.2 → NP_001003915.1  sodium-coupled monocarboxylate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_001003915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732495, BX005257
      Consensus CDS
      CCDS16512.1
      UniProtKB/Swiss-Prot
      Q49B93
      Related
      ENSMUSP00000047340.7, ENSMUST00000045972.13
      Conserved Domains (1) summary
      cl00456
      Location:3 → 531
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001177624.1 → NP_001171095.1  sodium-coupled monocarboxylate transporter 2 isoform 2

      See identical proteins and their annotated locations for NP_001171095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK165419, AL732495, BX005257
      Consensus CDS
      CCDS50656.1
      UniProtKB/Swiss-Prot
      Q0D2G1, Q49B93, Q6A4K8
      UniProtKB/TrEMBL
      B9EJ03
      Related
      ENSMUSP00000106655.3, ENSMUST00000111026.3
      Conserved Domains (1) summary
      cd11520
      Location:3 → 527
      SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      110427644..110479690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499489.4 → XP_006499552.1  sodium-coupled monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:1 → 339
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49B93.1 GenPept UniProtKB/Swiss-Prot:Q49B93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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