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    Tmem8b transmembrane protein 8B [ Mus musculus (house mouse) ]

    Gene ID: 242409, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem8bprovided by MGI
    Official Full Name
    transmembrane protein 8Bprovided by MGI
    Primary source
    MGI:MGI:2441680
    See related
    Ensembl:ENSMUSG00000078716 AllianceGenome:MGI:2441680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930500O05Rik
    Summary
    Predicted to be involved in cell-matrix adhesion. Predicted to be located in cell surface and plasma membrane. Orthologous to human TMEM8B (transmembrane protein 8B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 21.3), whole brain E14.5 (RPKM 8.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem8b in Genome Data Viewer
    Location:
    4 A5; 4 23.05 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43668971..43692668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43668971..43692668)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene family with sequence similarity 221, member B Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene olfactory receptor family 13 subfamily E member 8 Neighboring gene olfactory receptor family 13 subfamily J member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085508.2 → NP_001078977.1  transmembrane protein 8B isoform 1

      See identical proteins and their annotated locations for NP_001078977.1

      Status: VALIDATED

      Source sequence(s)
      AK029713, AK148848, CB248373, CO042254
      Consensus CDS
      CCDS51168.1
      UniProtKB/Swiss-Prot
      B1AWJ5, B9EJV2
      Related
      ENSMUSP00000103497.3, ENSMUST00000107865.9
      Conserved Domains (1) summary
      pfam12036
      Location:245 → 415
      DUF3522; Protein of unknown function (DUF3522)

    2. NM_001355718.1 → NP_001342647.1  transmembrane protein 8B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK029713, AK148848, CB248373, CO042254
      Conserved Domains (1) summary
      pfam12036
      Location:285 → 455
      DUF3522; Protein of unknown function (DUF3522)

    3. NM_001368840.1 → NP_001355769.1  transmembrane protein 8B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL732626
      Consensus CDS
      CCDS89738.1
      UniProtKB/TrEMBL
      B1AWJ4
      Related
      ENSMUSP00000103498.3, ENSMUST00000107866.9
      Conserved Domains (2) summary
      pfam09770
      Location:1 → 95
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12036
      Location:704 → 874
      DUF3522; Protein of unknown function (DUF3522)

    4. NM_001368841.1 → NP_001355770.1  transmembrane protein 8B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL732626
      Conserved Domains (1) summary
      pfam12036
      Location:285 → 401
      DUF3522; Protein of unknown function (DUF3522)

    5. NM_001368842.1 → NP_001355771.1  transmembrane protein 8B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL732626
      Conserved Domains (1) summary
      pfam12036
      Location:245 → 361
      DUF3522; Protein of unknown function (DUF3522)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43668971..43692668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250030.4 → XP_011248332.1  transmembrane protein 8B isoform X3

      See identical proteins and their annotated locations for XP_011248332.1

      UniProtKB/Swiss-Prot
      B1AWJ5, B9EJV2
      Related
      ENSMUSP00000103496.2, ENSMUST00000107864.8
      Conserved Domains (1) summary
      pfam12036
      Location:245 → 415
      DUF3522; Protein of unknown function (DUF3522)

    2. XM_030253531.2 → XP_030109391.1  transmembrane protein 8B isoform X2

      Conserved Domains (1) summary
      pfam12036
      Location:285 → 455
      DUF3522; Protein of unknown function (DUF3522)

    3. XM_011250028.4 → XP_011248330.1  transmembrane protein 8B isoform X1

      Conserved Domains (2) summary
      pfam09770
      Location:1 → 95
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12036
      Location:704 → 820
      DUF3522; Protein of unknown function (DUF3522)

    4. XM_036164110.1 → XP_036020003.1  transmembrane protein 8B isoform X3

      UniProtKB/Swiss-Prot
      B1AWJ5, B9EJV2
      Conserved Domains (1) summary
      pfam12036
      Location:245 → 415
      DUF3522; Protein of unknown function (DUF3522)

    5. XM_030253530.2 → XP_030109390.1  transmembrane protein 8B isoform X2

      Conserved Domains (1) summary
      pfam12036
      Location:285 → 455
      DUF3522; Protein of unknown function (DUF3522)

    6. XM_030253533.2 → XP_030109393.1  transmembrane protein 8B isoform X4

      Conserved Domains (1) summary
      pfam12036
      Location:285 → 401
      DUF3522; Protein of unknown function (DUF3522)

    7. XM_036164109.1 → XP_036020002.1  transmembrane protein 8B isoform X2

      Conserved Domains (1) summary
      pfam12036
      Location:285 → 455
      DUF3522; Protein of unknown function (DUF3522)

    8. XM_030253532.1 → XP_030109392.1  transmembrane protein 8B isoform X2

      Conserved Domains (1) summary
      pfam12036
      Location:285 → 455
      DUF3522; Protein of unknown function (DUF3522)

    RNA

    1. XR_001784142.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AWJ5.1 GenPept UniProtKB/Swiss-Prot:B1AWJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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