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    Snx14 sorting nexin 14 [ Mus musculus (house mouse) ]

    Gene ID: 244962, updated on 27-Nov-2024

    Summary

    Official Symbol
    Snx14provided by MGI
    Official Full Name
    sorting nexin 14provided by MGI
    Primary source
    MGI:MGI:2155664
    See related
    Ensembl:ENSMUSG00000032422 AllianceGenome:MGI:2155664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    YR-14; B830022K16; C330035N22Rik
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Involved in postsynaptic modulation of chemical synaptic transmission. Is active in synapse. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.9), CNS E18 (RPKM 4.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Snx14 in Genome Data Viewer
    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88258805..88320982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88376755..88438929, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24855 Neighboring gene microRNA 12205 Neighboring gene 5' nucleotidase, ecto Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10573 Neighboring gene STARR-seq mESC enhancer starr_24856 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9772 Neighboring gene small nucleolar RNA, C/D box 50A Neighboring gene small nucleolar RNA host gene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359958.2NP_001346887.2  sorting nexin-14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116713, CT025673
      UniProtKB/Swiss-Prot
      B0V2Q4, G3UWA3, Q8BHY8
      UniProtKB/TrEMBL
      G3UX33
      Related
      ENSMUSP00000133533.3, ENSMUST00000174806.9
      Conserved Domains (4) summary
      cd06877
      Location:564686
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:807911
      Nexin_C; Sorting nexin C terminal
    2. NM_172926.4NP_766514.3  sorting nexin-14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116713, CT025673
      Consensus CDS
      CCDS23387.2
      UniProtKB/Swiss-Prot
      B0V2Q4, G3UWA3, Q8BHY8
      UniProtKB/TrEMBL
      A0A6Q6RCM4
      Related
      ENSMUSP00000130116.3, ENSMUST00000165315.9
      Conserved Domains (4) summary
      cd06877
      Location:555677
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:798902
      Nexin_C; Sorting nexin C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      88258805..88320982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155012.1XP_036010905.1  sorting nexin-14 isoform X1

      UniProtKB/TrEMBL
      Q80XP2
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily