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    Hspbp1 HSPA (Hsp70) binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246146, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hspbp1provided by RGD
    Official Full Name
    HSPA (Hsp70) binding protein 1provided by RGD
    Primary source
    RGD:628677
    See related
    EnsemblRapid:ENSRNOG00000017795 AllianceGenome:RGD:628677
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity; molecular sequestering activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum and extracellular space. Orthologous to human HSPBP1 (HSPA (Hsp70) binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 147.1), Kidney (RPKM 110.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hspbp1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78194067..78217836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69165394..69189062)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72732418..72756087)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 150B Neighboring gene BR serine/threonine kinase 1 Neighboring gene uncharacterized LOC108349434 Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene transmembrane protein 86B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. Raynes DA, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786638
    2. CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. Al-Ramahi I, et al. J Biol Chem, 2006 Sep 8. PMID 16831871
    3. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Arndt V, et al. Mol Biol Cell, 2005 Dec. PMID 16207813, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hsp70-binding protein 1
    Names
    HSPA (heat shock 70) binding protein, cytoplasmic cochaperone 1
    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
    HSPA binding protein, cytoplasmic cochaperone 1
    heat shock protein-binding protein 1
    hsp70-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139261.1 → NP_640354.1  hsp70-binding protein 1

      See identical proteins and their annotated locations for NP_640354.1

      Status: PROVISIONAL

      Source sequence(s)
      AF187860
      UniProtKB/Swiss-Prot
      Q6IMX7
      Related
      ENSRNOP00000024251.3, ENSRNOT00000024251.7
      Conserved Domains (3) summary
      cd00020
      Location:198 → 299
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78194067..78217836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228250.5 → XP_006228312.1  hsp70-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228312.1

      UniProtKB/Swiss-Prot
      Q6IMX7, Q9JLF4
      UniProtKB/TrEMBL
      A6KNM8
      Conserved Domains (3) summary
      cd00020
      Location:198 → 299
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]

    2. XM_063280943.1 → XP_063137013.1  hsp70-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6IMX7, Q9JLF4
      UniProtKB/TrEMBL
      A6KNM8

    3. XM_006228248.2 → XP_006228310.1  hsp70-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006228310.1

      UniProtKB/Swiss-Prot
      Q6IMX7, Q9JLF4
      UniProtKB/TrEMBL
      A6KNM8
      Conserved Domains (3) summary
      cd00020
      Location:198 → 299
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08609
      Location:43 → 137
      Fes1; Nucleotide exchange factor Fes1
      sd00043
      Location:135 → 172
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IMX7.1 GenPept UniProtKB/Swiss-Prot:Q6IMX7

    Gene LinkOut

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