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    CG30098 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30098provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050098
    Locus tag
    Dmel_CG30098
    See related
    AllianceGenome:FB:FBgn0050098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG30098; SP221
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30098 in Genome Data Viewer
    Location:
    53C2-53C2; 2-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16354224..16355215, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12241729..12242720, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene wicked Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43416 Neighboring gene long non-coding RNA:CR45322

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. Gordon MD, et al. PLoS Pathog, 2008 Jul 25. PMID 18654628, Free PMC Article
    2. Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. Chen WY, et al. EMBO Rep, 2015 Apr. PMID 25666827, Free PMC Article
    3. Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons. Jetti SK, et al. Neuron, 2023 Nov 15. PMID 37611584
    4. Normal aging hyperactivates innate immunity and reduces the medical efficacy of minocycline in brain injury. Sanuki R, et al. Brain Behav Immun, 2019 Aug. PMID 30986429
    5. The Genomic Basis of Postponed Senescence in Drosophila melanogaster. Carnes MU, et al. PLoS One, 2015. PMID 26378456, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30098-PA
    NP_725573.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16354224..16355215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166171.2 → NP_725573.2  uncharacterized protein Dmel_CG30098 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725573.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V653
      Conserved Domains (2) summary
      smart00020
      Location:36 → 254
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:37 → 258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V653 Q4V653

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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