Nup153 nucleoporin 153 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup153provided by RGD
Official Full Name: nucleoporin 153provided by RGD
Primary source: RGD:3216
See related: EnsemblRapid:ENSRNOG00000001456 AllianceGenome:RGD:3216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NUCZINK
Summary: Enables several functions, including nuclear localization sequence binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including amyloid fibril formation; negative regulation of RNA export from nucleus; and nucleocytoplasmic transport. Located in annulate lamellae and nucleus. Part of nuclear pore nuclear basket. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 242.3), Spleen (RPKM 214.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (18178434..18231109)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (17972217..18024876)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (18358712..18411368)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH127428 (e-PCR)
- UniSTS:210738

C88147 (e-PCR)
- UniSTS:165868

RH141746 (e-PCR)
- UniSTS:223739

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in annulate lamellae	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	IEA Inferred from Electronic Annotation more info
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasmic side of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear pore complex protein Nup153

Names: 153 kDa nucleoporin; nucleoporin 153kD; nucleoporin Nup153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100470.1 → NP_001093940.1 nuclear pore complex protein Nup153

See identical proteins and their annotated locations for NP_001093940.1

Status: VALIDATED

Source sequence(s)

AA818240, CO574678, CV117688, L06821

UniProtKB/Swiss-Prot

P49791

UniProtKB/TrEMBL

A6J711, G3V662

Related

ENSRNOP00000001979.4, ENSRNOT00000001979.7

Conserved Domains (4) summary

sd00025
Location:662 → 681

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:722 → 750

zf-RanBP; Zn-finger in Ran binding protein and others

pfam08604
Location:114 → 629

Nup153; Nucleoporin Nup153-like

pfam10599
Location:1378 → 1468

Nup_retrotrp_bd; Retro-transposon transporting motif