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    muk1 guanyl-nucleotide exchange factor Muk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540384, updated on 18-Sep-2024

    Summary

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    Official Symbol
    muk1
    Official Full Name
    guanyl-nucleotide exchange factor Muk1
    Primary source
    PomBase:SPBC29A10.11c
    Locus tag
    SPOM_SPBC29A10.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    vps902; vps9b
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    Genomic context

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    See muk1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2563477..2565609, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CAF1 family ribonuclease Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Dbl8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene oxidative stress transcription coactivator/ribosome recycling protein Oxs1 Neighboring gene F0-ATPase subunit D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast. Tsukamoto Y, et al. Biochem Biophys Res Commun, 2015 Mar 20. PMID 25686494
    2. CUE domain-containing protein Vps901 is required for vacuolar protein transport in Schizosaccharomyces pombe. Nakase M, et al. Biosci Biotechnol Biochem, 2012. PMID 22484924
    3. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of both vps901 and vps902 genes completely abolished the mating process and responses to various stresses.
      Title: Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast.
    2. Deletion of vps902(+) had no effect on vacuolar transport, suggesting that only Vps901p functions in vacuolar protein transport in S. pombe.
      Title: CUE domain-containing protein Vps901 is required for vacuolar protein transport in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanyl-nucleotide exchange factor Muk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2563477..2565609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355777.2 → NP_001342780.1  guanyl-nucleotide exchange factor Muk1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      D2CFN7, O94388
      Conserved Domains (1) summary
      pfam02204
      Location:173 → 274
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein
    Heading Accession and Version

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