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    int6 translation initiation factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    int6
    Official Full Name
    translation initiation factor
    Primary source
    PomBase:SPBC646.09c
    Locus tag
    SPOM_SPBC646.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    tif305; yin6
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    Genomic context

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    See int6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (938621..940308, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene oxysterol binding protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP protein Nop56

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation. Bandyopadhyay A, et al. Mol Biol Cell, 2000 Nov. PMID 11071923, Free PMC Article
    2. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. Nemoto N, et al. J Mol Biol, 2010 Nov 26. PMID 20875427, Free PMC Article
    3. Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. Bandyopadhyay A, et al. J Biol Chem, 2002 Jan 18. PMID 11705997
    4. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Otero JH, et al. Cell Cycle, 2010 Jan 1. PMID 20016281, Free PMC Article
    5. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. Udagawa T, et al. J Biol Chem, 2008 Aug 8. PMID 18502752, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A transcript-specific eIF3 complex mediates global translational control of energy metabolism.
      Title: A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
    2. Results suggest that Cdc48, Yin6 and Moe1 act in the same protein complex to concertedly control ERAD and chromosome segregation.
      Title: Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation.
    3. the robust protein synthesis promoted by intact eIF3 appears to be a part of the requisites for sound Sty1 MAPK-dependent signaling governed by the activity of the Atf1 transcription factor
      Title: Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.
    4. In this study, proteasome-COP9-initiation factor proteasome subunit, Rpn7, was isolated as a high copy suppressor that rescued the proteasome defects in yin6 null cells.
      Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.
    5. Data show that Int6 acts to increase the transcriptional activity of Pap1.
      Title: Activation of AP-1-dependent transcription by a truncated translation initiation factor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 3 complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic 43S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3e IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      938621..940308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021275.3 → NP_595367.1  translation initiation factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595367.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94513
      Conserved Domains (2) summary
      pfam09440
      Location:16 → 150
      eIF3_N; eIF3 subunit 6 N terminal domain
      cl02111
      Location:310 → 391
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version

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