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    aps1 diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542890, updated on 18-Sep-2024

    Summary

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    Official Symbol
    aps1
    Official Full Name
    diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1
    Primary source
    PomBase:SPAC13G6.14
    Locus tag
    SPOM_SPAC13G6.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC24B11.03; stw1
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    Genomic context

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    See aps1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (200038..201517)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene chitin synthase I Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene calcipressin Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase. Ghosh S, et al. mBio, 2024 Aug 14. PMID 38940614, Free PMC Article
    2. Schizosaccharomyces pombe Aps1, a diadenosine 5',5' "-P1, P6-hexaphosphate hydrolase that is a member of the nudix (MutT) family of hydrolases: cloning of the gene and characterization of the purified enzyme. Ingram SW, et al. Biochemistry, 1999 Mar 23. PMID 10090752
    3. Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations. Ingram SW, et al. Biochem J, 2003 Feb 1. PMID 12387729, Free PMC Article
    4. Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe. Garza JA, et al. Biochemistry, 2009 Jul 7. PMID 19462967
    5. The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. Pöhlmann J, et al. PLoS Genet, 2014 Sep. PMID 25254656, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The specific Aps1 residues involved in binding of diadenosine oligophosphates and diphosphoinositol polyphosphates substrates were determined.
      Title: Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-hexaphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-adenosyl)-hexaphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-pentaphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables bis(5'-adenosyl)-triphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine hexaphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine pentaphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diadenosine polyphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      200038..201517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018241.3 → NP_592840.1  diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592840.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09790
      Conserved Domains (1) summary
      cd04666
      Location:43 → 198
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials