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    orb6 serine/threonine protein kinase Orb6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543441, updated on 18-Sep-2024

    Summary

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    Official Symbol
    orb6
    Official Full Name
    serine/threonine protein kinase Orb6
    Primary source
    PomBase:SPAC821.12
    Locus tag
    SPOM_SPAC821.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See orb6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1008263..1010318)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene gamma-glutamyl phosphate reductase Pro1 Neighboring gene P-type ATPase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe. Liu G, et al. PLoS One, 2012. PMID 22629372, Free PMC Article
    2. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Verde F, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636183, Free PMC Article
    3. Pak1 kinase controls cell shape through ribonucleoprotein granules. Magliozzi JO, et al. Elife, 2021 Jul 20. PMID 34282727, Free PMC Article
    4. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Tay YD, et al. Cell Rep, 2019 Feb 5. PMID 30726745, Free PMC Article
    5. Control of cell polarity in fission yeast by association of Orb6p kinase with the highly conserved protein methyltransferase Skb1p. Wiley DJ, et al. J Biol Chem, 2003 Jul 4. PMID 12646585

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pak1 kinase controls cell shape through ribonucleoprotein granules.
      Title: Pak1 kinase controls cell shape through ribonucleoprotein granules.
    2. Orb6 phosphorylation of Sec3 contributes to exocyst function in concert with exocyst protein Exo70.
      Title: Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
    3. The authors find that Orb6 kinase inhibits Sts5 recruitment into ribonucleoprotein granules, its association with processing (P) bodies, and degradation of Sts5-bound mRNAs by promoting Sts5 interaction with 14-3-3 protein Rad24.
      Title: Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5.
    4. Lrp1 proved to function upstream of Orb6 in cell morphogenesis
      Title: Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).
    5. our results suggest a model whereby autophosphorylation of Ser291 and phosphorylation of Thr456 by an upstream kinase promote Nak1/Orb6 complex formation and Orb6 activation.
      Title: Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe.
    6. The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
      Title: The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RAM/MOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of protein location in cell cortex of cell tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase Orb6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1008263..1010318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018563.3 → NP_593165.1  serine/threonine protein kinase Orb6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593165.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13310
      Conserved Domains (2) summary
      smart00220
      Location:93 → 392
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05629
      Location:91 → 461
      STKc_NDR_like_fungal; Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials