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    cmb1 cytosine-mismatch-binding protein 1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543595, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cmb1
    Official Full Name
    cytosine-mismatch-binding protein 1
    Primary source
    PomBase:SPAC4G9.11c
    Locus tag
    SPOM_SPAC4G9.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cmb1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2275503..2276209, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ornithine carbamoyltransferase Arg3 Neighboring gene retromer complex arrestin related endocytic adaptor ubunit Vps26 Neighboring gene gluconokinase Neighboring gene ncRNA Neighboring gene PMP22 family protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of the structure-specific DNA-binding protein Cmb1 from Schizosaccharomyces pombe. Sassoon J, et al. J Mol Biol, 2001 Jun 22. PMID 11399082
    2. The high mobility group domain protein Cmb1 of Schizosaccharomyces pombe binds to cytosines in base mismatches and opposite chemically altered guanines. Fleck O, et al. J Biol Chem, 1998 Nov 13. PMID 9804804
    3. Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage. Kunz C, et al. Biochem J, 2003 Jun 1. PMID 12617726, Free PMC Article
    4. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article
    5. SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast. Singh NS, et al. Curr Biol, 2011 Dec 6. PMID 22119525, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables adenine/cytosine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytosine/cytosine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytosine/thymine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mitochondrial promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitochondrial transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single cytosine insertion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymine/thymine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription initiation at mitochondrial promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    is_active_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosine-mismatch-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2275503..2276209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019125.3 → NP_593693.2  cytosine-mismatch-binding protein 1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10241
      UniProtKB/TrEMBL
      A0AAN2H832
    Nucleotide Protein
    Heading Accession and Version

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