RAB11FIP5 RAB11 family interacting protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB11FIP5provided by HGNC
Official Full Name: RAB11 family interacting protein 5provided by HGNC
Primary source: HGNC:HGNC:24845
See related: Ensembl:ENSG00000135631 MIM:605536; AllianceGenome:HGNC:24845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAF1; pp75; RIP11; gaf-1; rab11-FIP5
Summary: Enables gamma-tubulin binding activity. Involved in cellular response to acidic pH; negative regulation of adiponectin secretion; and regulation of protein localization to cell surface. Located in centriolar satellite and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 48.5), kidney (RPKM 16.7) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (73073382..73112948, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (73086356..73125920, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (73300510..73340076, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
Title: Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
Title: RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45.
Title: Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45.
The Rab-binding module of FERARI (factors for endosome recycling and Rab interactions) consists of Rab11FIP5 and rabenosyn-5, while the SNARE-interacting module comprises VPS45 and VIPAS39.
Title: FERARI is required for Rab11-dependent endocytic recycling.
FIP5-T276 phosphorylation occurs specifically during metaphase and anaphase.
Title: FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis.
FIP5-SNX18 complex plays a pivotal role in the polarized transport of apical proteins during apical lumen initiation in epithelial cells.
Title: Interaction between FIP5 and SNX18 regulates epithelial lumen formation.
These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland.
Title: Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes.
Title: The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GAF1__6771 (e-PCR)
- UniSTS:466195

D2S2111 (e-PCR)
- UniSTS:26391

RH78075 (e-PCR)
- UniSTS:7165

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	IDA Inferred from Direct Assay more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 5

Names: RAB11 family interacting protein 5 (class I); gamma-SNAP-associated factor 1; phosphoprotein pp75; rab11-interacting protein Rip11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371272.1 → NP_001358201.1 rab11 family-interacting protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

AC010913, AC012366

Consensus CDS

CCDS92776.1

UniProtKB/TrEMBL

A0A1B0GTL5

Related

ENSP00000489752.1, ENST00000486777.7

Conserved Domains (3) summary

PHA03247
Location:1121 → 1251

PHA03247; large tegument protein UL36; Provisional

pfam09457
Location:1272 → 1319

RBD-FIP; FIP domain

cl14603
Location:21 → 167

C2; C2 domain
NM_015470.3 → NP_056285.1 rab11 family-interacting protein 5 isoform 2

See identical proteins and their annotated locations for NP_056285.1

Status: VALIDATED

Source sequence(s)

AB020664, AC010913, AL117579

Consensus CDS

CCDS1923.1

UniProtKB/Swiss-Prot

O94939, Q9BXF6, Q9P0M1

Related

ENSP00000258098.6, ENST00000258098.6

Conserved Domains (2) summary

pfam09457
Location:601 → 648

RBD-FIP; FIP domain

cl14603
Location:21 → 167

C2; C2 domain