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    Slc12a8 solute carrier family 12, member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc12a8provided by RGD
    Official Full Name
    solute carrier family 12, member 8provided by RGD
    Primary source
    RGD:628730
    See related
    EnsemblRapid:ENSRNOG00000001792 AllianceGenome:RGD:628730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccc9
    Summary
    Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 115.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc12a8 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (80622000..80771674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67116876..67266548, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70344771..70499202, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene mucin 13, cell surface associated Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene uncharacterized LOC134481081 Neighboring gene uncharacterized LOC134481082 Neighboring gene zinc finger protein 148 Neighboring gene small nucleolar RNA SNORA36 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 8
    Names
    cation-chloride cotransporter 9
    solute carrier family 12 (potassium/chloride transporters), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153625.2 → NP_705889.2  solute carrier family 12 member 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q8CJI2, Q8CJI3
      UniProtKB/TrEMBL
      A6IRK4, F1M7M6
      Related
      ENSRNOP00000002439.6, ENSRNOT00000002439.9
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      80622000..80771674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248423.5 → XP_006248485.1  solute carrier family 12 member 8 isoform X1

      See identical proteins and their annotated locations for XP_006248485.1

      UniProtKB/Swiss-Prot
      Q8CJI2, Q8CJI3
      UniProtKB/TrEMBL
      A6IRK4, F1M7M6
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    2. XM_063270314.1 → XP_063126384.1  solute carrier family 12 member 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8CJI2, Q8CJI3
      UniProtKB/TrEMBL
      A6IRK4, F1M7M6
      Related
      ENSRNOP00000081818.2, ENSRNOT00000108813.2

    3. XM_039088051.2 → XP_038943979.1  solute carrier family 12 member 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G6I7, A6IRK9
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    4. XM_039088052.2 → XP_038943980.1  solute carrier family 12 member 8 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K244
      Conserved Domains (1) summary
      TIGR00930
      Location:49 → 264
      2a30; K-Cl cotransporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJI3.1 GenPept UniProtKB/Swiss-Prot:Q8CJI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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