Casp8ap2 caspase 8 associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp8ap2provided by MGI
Official Full Name: caspase 8 associated protein 2provided by MGI
Primary source: MGI:MGI:1349399
See related: Ensembl:ENSMUSG00000028282 AllianceGenome:MGI:1349399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FLASH; D4Ertd659e
Summary: Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 6.6), placenta adult (RPKM 3.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 14.27 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (32615462..32653271)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (32615470..32653271)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the functional interaction of E2A and FLASH play an important role in cell proliferation and cellular senescence via regulation of p21 expression in experimental glomerulonephritis.
Title: A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis.
Data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies.
Title: SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2.
Data show that homozygous deletion of FLASH results in early embryonic lethality.
Title: FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription.
This enzyme has an essential role in T-cell homeostasis and T-cell-mediated immunity.
Title: Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234888

AU015347 (e-PCR)
- UniSTS:167408

AA536675 (e-PCR)
- UniSTS:207606

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO polymer binding	ISO Inferred from Sequence Orthology more info
enables SUMO polymer binding	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Fas signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fas signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fas signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CASP8-associated protein 2

Names: FLICE-associated huge protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122978.2 → NP_001116450.1 CASP8-associated protein 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK142148, AL805973, CA526466

Consensus CDS

CCDS18016.1

UniProtKB/Swiss-Prot

B1AX74, Q9CSW2, Q9WUF3

Related

ENSMUSP00000136016.2, ENSMUST00000178925.8

Conserved Domains (3) summary

cd12202
Location:1896 → 1960

CASP8AP2; Caspase 8-associated protein 2 myb-like domain

TIGR04313
Location:1036 → 1156

aro_clust_Mycop; aromatic cluster surface protein

cl23720
Location:75 → 142

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_011997.3 → NP_036127.2 CASP8-associated protein 2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL805973, AL954737

Consensus CDS

CCDS18016.1

UniProtKB/Swiss-Prot

B1AX74, Q9CSW2, Q9WUF3

Related

ENSMUSP00000029950.4, ENSMUST00000029950.10

Conserved Domains (3) summary

cd12202
Location:1896 → 1960

CASP8AP2; Caspase 8-associated protein 2 myb-like domain

TIGR04313
Location:1036 → 1156

aro_clust_Mycop; aromatic cluster surface protein

cl23720
Location:75 → 142

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

32615462..32653271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537949.2 → XP_006538012.1 CASP8-associated protein 2 isoform X1

Conserved Domains (3) summary

cd12202
Location:1940 → 2004

CASP8AP2; Caspase 8-associated protein 2 myb-like domain

TIGR04313
Location:1080 → 1200

aro_clust_Mycop; aromatic cluster surface protein

cl23720
Location:119 → 186

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_006537950.3 → XP_006538013.1 CASP8-associated protein 2 isoform X2

Conserved Domains (3) summary

cd12202
Location:1938 → 2002

CASP8AP2; Caspase 8-associated protein 2 myb-like domain

TIGR04313
Location:1078 → 1198

aro_clust_Mycop; aromatic cluster surface protein

cl23720
Location:126 → 184

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)