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    Azi2 5-azacytidine induced gene 2 [ Mus musculus (house mouse) ]

    Gene ID: 27215, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Azi2provided by MGI
    Official Full Name
    5-azacytidine induced gene 2provided by MGI
    Primary source
    MGI:MGI:1351332
    See related
    Ensembl:ENSMUSG00000039285 AllianceGenome:MGI:1351332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ2; Nap1
    Summary
    Involved in negative regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T cell activation; dendritic cell differentiation; and dendritic cell proliferation. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human AZI2 (5-azacytidine induced 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.1), bladder adult (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Azi2 in Genome Data Viewer
    Location:
    9 F3; 9 69.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (117869510..117898866)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118040442..118069798)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein Neighboring gene predicted gene, 39450 Neighboring gene predicted gene, 26614 Neighboring gene STARR-seq mESC enhancer starr_25450 Neighboring gene predicted gene, 50606 Neighboring gene STARR-positive B cell enhancer ABC_E3864 Neighboring gene STARR-positive B cell enhancer ABC_E2921 Neighboring gene STARR-positive B cell enhancer mm9_chr9:117962449-117962749 Neighboring gene zinc finger, CW type with PWWP domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118059288-118059397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118105829-118106030 Neighboring gene C-X9-C motif containing 1 Neighboring gene predicted gene, 17399 Neighboring gene predicted gene, 53195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia. Wei M, et al. Pathog Dis, 2022 Jul 1. PMID 35595469
    2. Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Parker CC, et al. Nat Genet, 2016 Aug. PMID 27376237, Free PMC Article
    3. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. Miyagawa J, et al. Gene, 1999 Nov 29. PMID 10580148
    4. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1. Zhao W, et al. J Immunol, 2012 Jun 1. PMID 22539786
    5. Brain formation of oestrogen in the mouse: sex dimorphism in aromatase development. Hutchison JB, et al. J Steroid Biochem Mol Biol, 1994 Jun. PMID 8043507

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia.
      Title: AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia.
    2. AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs.
      Title: Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendritic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-azacytidine-induced protein 2
    Names
    NF-kappa-B-activating kinase-associated protein 1
    nak-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048146.2 → NP_001041611.1  5-azacytidine-induced protein 2 isoform b

      See identical proteins and their annotated locations for NP_001041611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site that is used in variant 1. It encodes isoform b that is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC157475, AI390224, AK134714
      Consensus CDS
      CCDS52959.1
      UniProtKB/Swiss-Prot
      Q9QYP6
      Related
      ENSMUSP00000114980.2, ENSMUST00000134433.8
      Conserved Domains (1) summary
      pfam12845
      Location:229 → 267
      TBD; TBD domain

    2. NM_001286507.1 → NP_001273436.1  5-azacytidine-induced protein 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that has shorter N-terminus and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI390224, AK036102
      UniProtKB/Swiss-Prot
      Q9QYP6
      Conserved Domains (1) summary
      pfam12845
      Location:82 → 124
      TBD; TBD domain

    3. NM_001286508.1 → NP_001273437.1  5-azacytidine-induced protein 2 isoform a

      See identical proteins and their annotated locations for NP_001273437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same protein (isoform a).
      Source sequence(s)
      AC157475, AI390224, AK030076, AV027010
      Consensus CDS
      CCDS40799.1
      UniProtKB/Swiss-Prot
      Q3TIN1, Q3V3R2, Q9CUI5, Q9QYP6
      Related
      ENSMUSP00000118765.2, ENSMUST00000133580.8
      Conserved Domains (1) summary
      pfam12845
      Location:229 → 278
      TBD; TBD domain

    4. NM_001421321.1 → NP_001408250.1  5-azacytidine-induced protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC157475

    5. NM_013727.4 → NP_038755.1  5-azacytidine-induced protein 2 isoform a

      See identical proteins and their annotated locations for NP_038755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a). Variants 1 and 4 encode the same protein.
      Source sequence(s)
      AC157475, AI390224, AK030076, AK153477, AV027010
      Consensus CDS
      CCDS40799.1
      UniProtKB/Swiss-Prot
      Q3TIN1, Q3V3R2, Q9CUI5, Q9QYP6
      Related
      ENSMUSP00000044350.6, ENSMUST00000044454.12
      Conserved Domains (1) summary
      pfam12845
      Location:229 → 278
      TBD; TBD domain

    RNA

    1. NR_185293.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157475

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      117869510..117898866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155042.1 → XP_036010935.1  5-azacytidine-induced protein 2 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:46 → 220
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12845
      Location:227 → 261
      TBD; TBD domain

    2. XM_006512148.3 → XP_006512211.1  5-azacytidine-induced protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006512211.1

      Conserved Domains (2) summary
      COG1196
      Location:46 → 220
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12845
      Location:227 → 261
      TBD; TBD domain

    3. XM_036155041.1 → XP_036010934.1  5-azacytidine-induced protein 2 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:46 → 220
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12845
      Location:227 → 261
      TBD; TBD domain

    4. XM_036155040.1 → XP_036010933.1  5-azacytidine-induced protein 2 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:46 → 220
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12845
      Location:227 → 261
      TBD; TBD domain

    5. XM_006512149.3 → XP_006512212.1  5-azacytidine-induced protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006512212.1

      Conserved Domains (1) summary
      pfam12845
      Location:80 → 131
      TBD; TBD domain

    RNA

    1. XR_004935444.1 RNA Sequence

    2. XR_004935443.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYP6.1 GenPept UniProtKB/Swiss-Prot:Q9QYP6

    Gene LinkOut

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