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    Mrpl39 mitochondrial ribosomal protein L39 [ Mus musculus (house mouse) ]

    Gene ID: 27393, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl39provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L39provided by MGI
    Primary source
    MGI:MGI:1351620
    See related
    Ensembl:ENSMUSG00000022889 AllianceGenome:MGI:1351620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF22; Rpml5; MRP-L5; C21orf8
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.9), CNS E11.5 (RPKM 11.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl39 in Genome Data Viewer
    Location:
    16 C3.3; 16 46.92 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84515068..84532261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84718281..84735244, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930529L06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3170 Neighboring gene STARR-positive B cell enhancer ABC_E10920 Neighboring gene STARR-positive B cell enhancer ABC_E262 Neighboring gene Mir155 host gene (non-protein coding) Neighboring gene microRNA 155 Neighboring gene STARR-positive B cell enhancer ABC_E10921 Neighboring gene predicted gene, 26153 Neighboring gene predicted gene, 32202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
    2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial genome maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL39
    Names
    39S ribosomal protein L39, mitochondrial
    L39mt
    MRP-L39
    ribosomal protein, mitochondrial, L5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384093.1 → NP_001371022.1  large ribosomal subunit protein mL39 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT027693
      Conserved Domains (1) summary
      PLN02908
      Location:27 → 270
      PLN02908; threonyl-tRNA synthetase

    2. NM_001384095.1 → NP_001371024.1  large ribosomal subunit protein mL39 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT027693
      UniProtKB/TrEMBL
      Q8CCX9
      Conserved Domains (1) summary
      PLN02908
      Location:27 → 270
      PLN02908; threonyl-tRNA synthetase

    3. NM_001384096.1 → NP_001371025.1  large ribosomal subunit protein mL39 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT027693
      Conserved Domains (1) summary
      PRK00413
      Location:4 → 161
      thrS; threonyl-tRNA synthetase; Reviewed

    4. NM_017404.5 → NP_059100.3  large ribosomal subunit protein mL39 isoform 1

      See identical proteins and their annotated locations for NP_059100.3

      Status: VALIDATED

      Source sequence(s)
      AK007681, CT027693
      Consensus CDS
      CCDS57035.1
      UniProtKB/Swiss-Prot
      A6X954, Q91YK5, Q9D8U5, Q9JKF7
      UniProtKB/TrEMBL
      Q8CCX9
      Related
      ENSMUSP00000112283.2, ENSMUST00000116584.2
      Conserved Domains (1) summary
      cd01667
      Location:73 → 127
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      84515068..84532261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159970.1 → XP_036015863.1  large ribosomal subunit protein mL39 isoform X1

      Conserved Domains (2) summary
      PLN02908
      Location:144 → 316
      PLN02908; threonyl-tRNA synthetase
      cl28922
      Location:63 → 171
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_017317025.3 → XP_017172514.1  large ribosomal subunit protein mL39 isoform X4

      Conserved Domains (1) summary
      PRK00413
      Location:4 → 161
      thrS; threonyl-tRNA synthetase; Reviewed

    3. XM_036159972.1 → XP_036015865.1  large ribosomal subunit protein mL39 isoform X3

      Conserved Domains (2) summary
      PLN02908
      Location:144 → 316
      PLN02908; threonyl-tRNA synthetase
      cl28922
      Location:63 → 171
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_036159971.1 → XP_036015864.1  large ribosomal subunit protein mL39 isoform X2

      Conserved Domains (2) summary
      PLN02908
      Location:144 → 316
      PLN02908; threonyl-tRNA synthetase
      cl28922
      Location:63 → 171
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKF7.4 GenPept UniProtKB/Swiss-Prot:Q9JKF7

    Gene LinkOut

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