U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    APOE apolipoprotein E [ Bos taurus (domestic cattle) ]

    Gene ID: 281004, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    APOEprovided by VGNC
    Official Full Name
    apolipoprotein Eprovided by VGNC
    Primary source
    VGNC:VGNC:52178
    See related
    BGD:BT10400; Ensembl:ENSBTAG00000010123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See APOE in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (52637880..52640577)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 2 Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene small ribosomal subunit protein eS17-like Neighboring gene apolipoprotein C4

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Distribution of apolipoprotein E among lipoprotein fractions in the lactating cow. Takahashi Y, et al. Comp Biochem Physiol B Biochem Mol Biol, 2003 Dec. PMID 14662312
    2. Bovine apolipoprotein E in plasma: increase of ApoE concentration induced by fasting and distribution in lipoprotein fractions. Takahashi Y, et al. J Vet Med Sci, 2003 Feb. PMID 12655114
    3. Isolation, sequencing, and expression analysis of a bovine apolipoprotein E (APOE) cDNA and chromosomal localization of the APOE locus. Brzozowska A, et al. Mamm Genome, 1993. PMID 8422503
    4. Cloning and sequencing of bovine apolipoprotein E complementary DNA and molecular evolution of apolipoproteins E, C-I, and C-II. Yang YW, et al. J Mol Evol, 1991 Jun. PMID 1908018
    5. Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows. Bernabucci U, et al. J Dairy Sci, 2004 Sep. PMID 15375048

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
      Title: Effects of nonesterified fatty acids on the synthesis and assembly of very low density lipoprotein in bovine hepatocytes in vitro.
    2. apoE-containing particles, which increased during the lactating stage, were not associated with HDL particles, and lipid-free forms were included in cow plasma
      Title: Distribution of apolipoprotein E among lipoprotein fractions in the lactating cow.
    3. Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
      Title: Bovine apolipoprotein E in plasma: increase of ApoE concentration induced by fasting and distribution in lipoprotein fractions.
    4. after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver
      Title: Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables very-low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of intermediate-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    apolipoprotein E
    Names
    apo-E

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173991.2 → NP_776416.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_776416.1

      Status: PROVISIONAL

      Source sequence(s)
      X64839
      UniProtKB/Swiss-Prot
      Q03247, Q3T006, Q5E967
      UniProtKB/TrEMBL
      A7YWR0
      Related
      ENSBTAP00000013354.6, ENSBTAT00000013354.6
      Conserved Domains (1) summary
      pfam01442
      Location:85 → 272
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      52637880..52640577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005219148.5 → XP_005219205.2  apolipoprotein E isoform X1

      UniProtKB/TrEMBL
      A0A140T881, A0A3Q1LPF0
      Related
      ENSBTAP00000056793.2, ENSBTAT00000086136.2
      Conserved Domains (1) summary
      pfam01442
      Location:118 → 305
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03247.1 GenPept UniProtKB/Swiss-Prot:Q03247

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials