NCF1 neutrophil cytosolic factor 1 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: NCF1
Gene description: neutrophil cytosolic factor 1
See related: BGD:BT29391; Ensembl:ENSBTAG00000003305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	25	NC_037352.1 (32757994..32773107, complement)

Chromosome 25 - NC_037352.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
Title: Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
Title: Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli.
A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C.
Title: Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction.

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General gene information

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Markers

NCF1 (e-PCR)
- UniSTS:278816

Ncf1 (e-PCR), detects polymorphism
- UniSTS:228517

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in respiratory burst	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neutrophil cytosol factor 1

Names: 47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; neutrophil NADPH oxidase factor 1; neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1); neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); p47-phox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174119.5 → NP_776544.1 neutrophil cytosol factor 1

See identical proteins and their annotated locations for NP_776544.1

Status: VALIDATED

Source sequence(s)

BC103145, NKLS02000025

UniProtKB/Swiss-Prot

O77774, Q5E9R8

UniProtKB/TrEMBL

A0A452DHY1

Related

ENSBTAP00070031335.1, ENSBTAT00070052191.1

Conserved Domains (5) summary

cd06887
Location:6 → 123

PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase

cd12021
Location:160 → 212

SH3_p47phox_1; First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1

cd12022
Location:230 → 282

SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1

pfam08944
Location:332 → 391

p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain

pfam16621
Location:282 → 331

NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1