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    SELE selectin E [ Bos taurus (domestic cattle) ]

    Gene ID: 281484, updated on 1-Jan-2025

    Summary

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    Official Symbol
    SELEprovided by VGNC
    Official Full Name
    selectin Eprovided by VGNC
    Primary source
    VGNC:VGNC:34421
    See related
    BGD:BT10975; Ensembl:ENSBTAG00000007307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SELE in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (37372253..37384927, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene selectin P Neighboring gene selectin L Neighboring gene uncharacterized LOC132342460 Neighboring gene uncharacterized LOC132342461 Neighboring gene methyltransferase like 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nguyen M, et al. Nature, 1993 Sep 16. PMID 7690465
    2. Hypoxia inhibits pulmonary artery endothelial cell apoptosis via the e-selectin/biliverdin reductase pathway. Song S, et al. Microvasc Res, 2016 Jul. PMID 27033411
    3. Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows. Chen X, et al. PLoS One, 2017. PMID 28419109, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E-selectin
    Names
    CD62 antigen-like family member E
    ELAM-1
    LECAM2
    endothelial adhesion molecule 1
    endothelial leukocyte adhesion molecule 1
    leukocyte-endothelial cell adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174181.2 → NP_776606.1  E-selectin precursor

      See identical proteins and their annotated locations for NP_776606.1

      Status: PROVISIONAL

      Source sequence(s)
      L12039
      UniProtKB/Swiss-Prot
      A6QP78, P98107
      UniProtKB/TrEMBL
      A0AAA9RUC8
      Related
      ENSBTAP00000009612.5, ENSBTAT00000009612.7
      Conserved Domains (3) summary
      cd03592
      Location:23 → 141
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:146 → 176
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl27761
      Location:201 → 421
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37372253..37384927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001502054.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98107.1 GenPept UniProtKB/Swiss-Prot:P98107

    Gene LinkOut

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