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    INPP1 inositol polyphosphate-1-phosphatase [ Bos taurus (domestic cattle) ]

    Gene ID: 281869, updated on 27-Dec-2024

    Summary

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    Official Symbol
    INPP1provided by VGNC
    Official Full Name
    inositol polyphosphate-1-phosphataseprovided by VGNC
    Primary source
    VGNC:VGNC:30208
    See related
    BGD:BT12034; Ensembl:ENSBTAG00000007584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See INPP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (5934745..5970809, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104971101 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene chromosome 2 C2orf88 homolog Neighboring gene protein kish-A-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells. York JD, et al. J Mol Biol, 1994 Feb 18. PMID 8107142
    2. Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. York JD, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2175905, Free PMC Article
    3. Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution. York JD, et al. Biochemistry, 1994 Nov 15. PMID 7947723
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol-1,4-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol polyphosphate 1-phosphatase
    Names
    IPP
    IPPase
    NP_776789.1
    XP_005202248.1
    XP_005202249.1
    XP_010800092.1
    XP_010800093.1
    XP_024854514.1
    XP_059747643.1
    XP_059747661.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174364.2 → NP_776789.1  inositol polyphosphate 1-phosphatase

      See identical proteins and their annotated locations for NP_776789.1

      Status: PROVISIONAL

      Source sequence(s)
      M55916
      UniProtKB/Swiss-Prot
      P21327
      Related
      ENSBTAP00000009977.4, ENSBTAT00000009977.5
      Conserved Domains (1) summary
      cd01640
      Location:4 → 388
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5934745..5970809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202192.4 → XP_005202249.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_005202249.1

      UniProtKB/Swiss-Prot
      P21327, Q1RMJ2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 388
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

    2. XM_059891660.1 → XP_059747643.1  inositol polyphosphate 1-phosphatase isoform X1

      UniProtKB/Swiss-Prot
      P21327, Q1RMJ2

    3. XM_059891678.1 → XP_059747661.1  inositol polyphosphate 1-phosphatase isoform X3

    4. XM_005202191.5 → XP_005202248.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_005202248.1

      UniProtKB/Swiss-Prot
      P21327, Q1RMJ2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 388
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

    5. XM_010801791.4 → XP_010800093.1  inositol polyphosphate 1-phosphatase isoform X2

      Conserved Domains (1) summary
      cl00289
      Location:79 → 340
      FIG; FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in ...

    6. XM_010801790.4 → XP_010800092.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_010800092.1

      UniProtKB/Swiss-Prot
      P21327, Q1RMJ2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 388
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

    7. XM_024998746.2 → XP_024854514.1  inositol polyphosphate 1-phosphatase isoform X1

      UniProtKB/Swiss-Prot
      P21327, Q1RMJ2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 388
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21327.2 GenPept UniProtKB/Swiss-Prot:P21327

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