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    TRPC4 transient receptor potential cation channel subfamily C member 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 282102, updated on 29-Jan-2025

    Summary

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    Official Symbol
    TRPC4provided by VGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 4provided by VGNC
    Primary source
    VGNC:VGNC:36383
    See related
    BGD:BT20330; Ensembl:ENSBTAG00000009405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TRPC4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (23965281..24173431)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346748 Neighboring gene ubiquitin fold modifier 1 Neighboring gene uncharacterized LOC112449047 Neighboring gene periostin Neighboring gene uncharacterized LOC112449048

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing and tissue specific expression of the 5' truncated bCCE 1 variant bCCE 1delta514. Freichel M, et al. FEBS Lett, 1998 Feb 6. PMID 9498815
    2. A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. Philipp S, et al. EMBO J, 1996 Nov 15. PMID 8947038, Free PMC Article
    3. Interaction between TRPC channel subunits in endothelial cells. Antoniotti S, et al. J Recept Signal Transduct Res, 2006. PMID 16818374
    4. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Freichel M, et al. Nat Cell Biol, 2001 Feb. PMID 11175743
    5. TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells. Philipp S, et al. J Biol Chem, 2000 Aug 4. PMID 10816590

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRPC channel subunits 1 and 4 interact in bovine endothelial cells
      Title: Interaction between TRPC channel subunits in endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables store-operated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short transient receptor potential channel 4
    Names
    CCE1
    capacitative calcium entry channel 1
    transient receptor potential cation channel TRPC4 middle region 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174478.2 → NP_776903.1  short transient receptor potential channel 4

      See identical proteins and their annotated locations for NP_776903.1

      Status: PROVISIONAL

      Source sequence(s)
      X99792
      UniProtKB/Swiss-Prot
      P79100
      Conserved Domains (2) summary
      TIGR00870
      Location:19 → 751
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:124 → 169
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23965281..24173431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010810662.4 → XP_010808964.1  short transient receptor potential channel 4 isoform X1

      See identical proteins and their annotated locations for XP_010808964.1

      UniProtKB/Swiss-Prot
      P79100
      Conserved Domains (2) summary
      TIGR00870
      Location:19 → 751
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:124 → 169
      ANK; ANK repeat [structural motif]

    2. XM_015473750.3 → XP_015329236.1  short transient receptor potential channel 4 isoform X1

      UniProtKB/Swiss-Prot
      P79100
      Related
      ENSBTAP00070014098.1, ENSBTAT00070023774.1
      Conserved Domains (2) summary
      TIGR00870
      Location:19 → 751
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:124 → 169
      ANK; ANK repeat [structural motif]

    3. XM_059891956.1 → XP_059747939.1  short transient receptor potential channel 4 isoform X1

      UniProtKB/Swiss-Prot
      P79100

    4. XM_059891958.1 → XP_059747941.1  short transient receptor potential channel 4 isoform X1

      UniProtKB/Swiss-Prot
      P79100

    5. XM_059891957.1 → XP_059747940.1  short transient receptor potential channel 4 isoform X1

      UniProtKB/Swiss-Prot
      P79100

    6. XM_015473751.3 → XP_015329237.1  short transient receptor potential channel 4 isoform X1

      UniProtKB/Swiss-Prot
      P79100
      Conserved Domains (2) summary
      TIGR00870
      Location:19 → 751
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:124 → 169
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79100.2 GenPept UniProtKB/Swiss-Prot:P79100

    Gene LinkOut

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