U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PTGER4 prostaglandin E receptor 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 282331, updated on 30-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    PTGER4provided by VGNC
    Official Full Name
    prostaglandin E receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:33504
    See related
    BGD:BT21162; EnsemblRapid:ENSBTAG00070008535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ep4
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTGER4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (33747129..33760294, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene uncharacterized LOC104975271

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor. Maślanka T, et al. Vet Immunol Immunopathol, 2014 Aug 15. PMID 25001909
    2. Exploring cumulus-oocyte-complex-oviductal cell interactions: gene profiling in the bovine oviduct. Gabler C, et al. J Physiol Pharmacol, 2008 Dec. PMID 19261969
    3. Molecular cloning and characterization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy. Arosh JA, et al. Endocrinology, 2003 Jul. PMID 12810564
    4. Lysophosphatidic acid modulates prostaglandin signalling in bovine steroidogenic luteal cells. Kowalczyk-Zieba I, et al. Prostaglandins Other Lipid Mediat, 2015 Sep. PMID 26482178
    5. Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle. Huang N, et al. Prostaglandins Other Lipid Mediat, 2015 Sep. PMID 26319698

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that lysophosphatidic acid (LPA) up-regulates expression of SLCO2A1 (prostaglandin [PG] transporter), PTGER2/PTGER4 (PG receptors EP2/EP4), and mPGES1/cPGES (microsomal/cytosolic PG E synthases) in luteal cells.
      Title: Lysophosphatidic acid modulates prostaglandin signalling in bovine steroidogenic luteal cells.
    2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor).
      Title: Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle.
    3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
      Title: Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
    4. Quantitative RT-PCR revealed significant higher expression of EP2 and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct
      Title: Exploring cumulus-oocyte-complex-oviductal cell interactions: gene profiling in the bovine oviduct.
    5. EP4 is undetectable in endometrium and myometrium during the estrous cycle
      Title: Molecular cloning and characterization of bovine prostaglandin E2 receptors EP2 and EP4: expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    PGE receptor, EP4 subtype
    PGE2 receptor EP4 subtype
    prostaglandin E receptor 4 (subtype EP4)
    prostanoid EP4 receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174589.2 → NP_777014.1  prostaglandin E2 receptor EP4 subtype

      See identical proteins and their annotated locations for NP_777014.1

      Status: PROVISIONAL

      Source sequence(s)
      AF539403
      UniProtKB/Swiss-Prot
      Q8MJ08
      Related
      ENSBTAP00070011392.1, ENSBTAT00070019250.1
      Conserved Domains (2) summary
      pfam00001
      Location:34 → 335
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29 → 216
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33747129..33760294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010816781.4 → XP_010815083.1  prostaglandin E2 receptor EP4 subtype isoform X1

      See identical proteins and their annotated locations for XP_010815083.1

      UniProtKB/TrEMBL
      F1MZJ8
      Conserved Domains (2) summary
      pfam00001
      Location:34 → 335
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29 → 216
      7tm_4; Olfactory receptor

    2. XM_005221540.5 → XP_005221597.1  prostaglandin E2 receptor EP4 subtype isoform X1

      See identical proteins and their annotated locations for XP_005221597.1

      UniProtKB/TrEMBL
      F1MZJ8
      Conserved Domains (2) summary
      pfam00001
      Location:34 → 335
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29 → 216
      7tm_4; Olfactory receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MJ08.1 GenPept UniProtKB/Swiss-Prot:Q8MJ08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.