PRDX6 peroxiredoxin 6 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRDX6provided by VGNC
Official Full Name: peroxiredoxin 6provided by VGNC
Primary source: VGNC:VGNC:33304
See related: Ensembl:ENSBTAG00000004855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: AOP2; LPCAT-5
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (54932648..54942564)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study demonstrated involvement of cytosolic and calcium-independent phospholipase A(2) and the contribution of cyclooxygenase-2 products in E. coli invasion of brain microvascular endothelial cells
Title: Involvement of PKCα-MAPK/ERK-phospholipase A(2) pathway in the Escherichia coli invasion of brain microvascular endothelial cells.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by iPLA2.
Title: Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells.
PRDX6 upregulation in cumulus-oocyte complexes during in vitro maturation is mutually regulated by both cell types.
Title: Peroxiredoxin 6 is upregulated in bovine oocytes and cumulus cells during in vitro maturation: role of intercellular communication.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

LOC343479 (e-PCR)
- UniSTS:278683

PRDX6 (e-PCR)
- UniSTS:278952

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: peroxiredoxin-6

Names: 1-Cys PRX; 1-Cys peroxiredoxin; LPC acyltransferase 5; NSGPx; PHGPx; acidic calcium-independent phospholipase A2; aiPLA2; anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2); antioxidant protein 2; calcium-independent phospholipase A2; ciliary body glutathione peroxidase; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase

NP_777068.1

EC 1.11.1.27

EC 2.3.1.23

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174643.1 → NP_777068.1 peroxiredoxin-6

See identical proteins and their annotated locations for NP_777068.1

Status: PROVISIONAL

Source sequence(s)

AF090194

UniProtKB/Swiss-Prot

O77834, Q5E9F3

Related

ENSBTAP00000006383.5, ENSBTAT00000006383.6

Conserved Domains (1) summary

cd03016
Location:7 → 222

PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...