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    SIGLEC17P sialic acid binding Ig like lectin 17, pseudogene [ Homo sapiens (human) ]

    Gene ID: 284367, updated on 22-Oct-2024

    Summary

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    Official Symbol
    SIGLEC17Pprovided by HGNC
    Official Full Name
    sialic acid binding Ig like lectin 17, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:15604
    See related
    Ensembl:ENSG00000291114 AllianceGenome:HGNC:15604
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPC078; SIGLECP2; SIGLECP3
    Expression
    Broad expression in lung (RPKM 3.9), spleen (RPKM 2.3) and 15 other tissues See more
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    Genomic context

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    See SIGLEC17P in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51167328..51173524)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54255942..54262138)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51670585..51676780)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904749 Neighboring gene sialic acid binding Ig like lectin 7 Neighboring gene uncharacterized LOC101928517 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51660802-51661000 Neighboring gene Sharpr-MPRA regulatory region 7523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51684473-51685444 Neighboring gene uncharacterized LOC107985327 Neighboring gene sialic acid binding Ig like lectin 20, pseudogene Neighboring gene zinc finger DHHC-type palmitoyltransferase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15010

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study. Shen X, et al. Cell Biol Int, 2023 Jan. PMID 36183365
    2. Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Wang X, et al. Proc Natl Acad Sci U S A, 2012 Jun 19. PMID 22665810, Free PMC Article
    3. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. Yousef GM, et al. Gene, 2002 Mar 20. PMID 11943481
    4. A second uniquely human mutation affecting sialic acid biology. Angata T, et al. J Biol Chem, 2001 Oct 26. PMID 11546777
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study.
      Title: The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • sialic acid binding Ig-like lectin, pseudogene 3
    • silec pseudogene-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_047529.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC063977, AK301336, BC041072
      Related
      ENST00000614626.3

    2. NR_047530.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1.
      Source sequence(s)
      AC063977, BC041072
      Related
      ENST00000618545.5

    3. NR_047531.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon compared to variant 1.
      Source sequence(s)
      AC063977, AF150143, BC041072
      Related
      ENST00000611992.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51167328..51173524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54255942..54262138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_002804.2: Suppressed sequence

      Description
      NR_002804.2: This RefSeq was permanently suppressed because it contains intronic sequence.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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