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    LIN9 lin-9 DREAM MuvB core complex component [ Homo sapiens (human) ]

    Gene ID: 286826, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LIN9provided by HGNC
    Official Full Name
    lin-9 DREAM MuvB core complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:30830
    See related
    Ensembl:ENSG00000183814 MIM:609375; AllianceGenome:HGNC:30830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TGS; BARA; TGS1; TGS2; Lin-9; BARPsv
    Summary
    This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LIN9 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226231149..226309767, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225419172..225497821, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226418850..226497468, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2647 Neighboring gene Sharpr-MPRA regulatory region 4175 Neighboring gene Mix paired-like homeobox Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226495998-226496764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1882 Neighboring gene small nucleolar RNA U13 Neighboring gene Y-box binding protein 1 pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mip/LIN-9 can inhibit cell proliferation independent of the pocket proteins. Pilkinton M, et al. Blood Cells Mol Dis, 2007 Nov-Dec. PMID 17618148, Free PMC Article
    2. Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors. Sahni JM, et al. Cancer Res, 2017 Oct 1. PMID 28807940, Free PMC Article
    3. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. Eckerdt F, et al. PLoS One, 2014. PMID 24475316, Free PMC Article
    4. Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. Calvisi DF, et al. Hepatology, 2011 Apr. PMID 21480327
    5. Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. Gagrica S, et al. EMBO J, 2004 Nov 24. PMID 15538385, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
      Title: LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.
    2. High LIN9 expression is associated with Triple-negative breast cancers.
      Title: Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.
    3. The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells.
      Title: Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.
    4. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
      Title: LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.
    5. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.
      Title: A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).
    6. Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
      Title: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.
    7. inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen
      Title: Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
    10. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction.
      Title: Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-9 homolog
    Names
    TUDOR gene similar protein
    beta subunit-associated regulator of apoptosis
    lin-9 homolog
    pRB-associated protein
    rb related pathway actor
    type I interferon receptor beta chain-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270409.1 → NP_001257338.1  protein lin-9 homolog isoform 2

      See identical proteins and their annotated locations for NP_001257338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AF190323, AL359742, BC045625, BX284931
      UniProtKB/TrEMBL
      H7C4T7
      Related
      ENSP00000418121.1, ENST00000460719.5
      Conserved Domains (1) summary
      pfam06584
      Location:108 → 212
      DIRP; DIRP

    2. NM_001270410.2 → NP_001257339.1  protein lin-9 homolog isoform 3

      See identical proteins and their annotated locations for NP_001257339.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AF190323, AL359742, BC065302, BX284931
      Consensus CDS
      CCDS91164.1
      UniProtKB/TrEMBL
      H0Y322, Q6P142
      Related
      ENSP00000355773.2, ENST00000366808.6
      Conserved Domains (1) summary
      pfam06584
      Location:75 → 179
      DIRP; DIRP

    3. NM_001366237.1 → NP_001353166.1  protein lin-9 homolog isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359742, BX284931
      UniProtKB/TrEMBL
      H7C4T7
      Conserved Domains (1) summary
      pfam06584
      Location:143 → 247
      DIRP

    4. NM_001366238.1 → NP_001353167.1  protein lin-9 homolog isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL359742, BX284931
      UniProtKB/TrEMBL
      H7C4T7
      Conserved Domains (1) summary
      pfam06584
      Location:142 → 246
      DIRP

    5. NM_001366239.1 → NP_001353168.1  protein lin-9 homolog isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359742, BX284931
      UniProtKB/TrEMBL
      H7C4T7
      Conserved Domains (1) summary
      pfam06584
      Location:143 → 247
      DIRP; DIRP

    6. NM_001366240.1 → NP_001353169.1  protein lin-9 homolog isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359742, BX284931
      UniProtKB/TrEMBL
      H7C4T7
      Conserved Domains (1) summary
      pfam06584
      Location:34 → 138
      DIRP

    7. NM_001366241.1 → NP_001353170.1  protein lin-9 homolog isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359742, BX284931
      Consensus CDS
      CCDS91164.1
      UniProtKB/TrEMBL
      H0Y322, Q6P142
      Conserved Domains (1) summary
      pfam06584
      Location:75 → 179
      DIRP; DIRP

    8. NM_001366245.2 → NP_001353174.1  protein lin-9 homolog isoform 8

      Status: REVIEWED

      Source sequence(s)
      AF190324, BX284931
      Consensus CDS
      CCDS91165.1
      UniProtKB/Swiss-Prot
      Q5TKA1, Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1
      UniProtKB/TrEMBL
      Q6P142
      Related
      ENSP00000505590.1, ENST00000681046.1
      Conserved Domains (1) summary
      pfam06584
      Location:127 → 231
      DIRP; DIRP

    9. NM_173083.3 → NP_775106.2  protein lin-9 homolog isoform 1

      See identical proteins and their annotated locations for NP_775106.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AF190323, AL359742, BC045625
      Consensus CDS
      CCDS1553.1
      UniProtKB/TrEMBL
      H7C4T7
      Related
      ENSP00000329102.5, ENST00000328205.9
      Conserved Domains (1) summary
      pfam06584
      Location:143 → 247
      DIRP; DIRP

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      226231149..226309767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001084.2 → XP_016856573.2  protein lin-9 homolog isoform X3

    2. XM_047418546.1 → XP_047274502.1  protein lin-9 homolog isoform X2

    3. XM_024446565.2 → XP_024302333.2  protein lin-9 homolog isoform X1

    4. XM_047418553.1 → XP_047274509.1  protein lin-9 homolog isoform X6

    5. XM_006711767.5 → XP_006711830.1  protein lin-9 homolog isoform X5

      See identical proteins and their annotated locations for XP_006711830.1

      UniProtKB/TrEMBL
      H0Y322, Q6P142
      Conserved Domains (1) summary
      pfam06584
      Location:75 → 179
      DIRP; DIRP

    6. XM_047418556.1 → XP_047274512.1  protein lin-9 homolog isoform X7

    7. XM_011544173.3 → XP_011542475.2  protein lin-9 homolog isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      225419172..225497821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336155.1 → XP_054192130.1  protein lin-9 homolog isoform X3

    2. XM_054336154.1 → XP_054192129.1  protein lin-9 homolog isoform X2

    3. XM_054336153.1 → XP_054192128.1  protein lin-9 homolog isoform X1

    4. XM_054336158.1 → XP_054192133.1  protein lin-9 homolog isoform X6

    5. XM_054336157.1 → XP_054192132.1  protein lin-9 homolog isoform X5

      UniProtKB/TrEMBL
      H0Y322

    6. XM_054336156.1 → XP_054192131.1  protein lin-9 homolog isoform X4

    7. XM_054336159.1 → XP_054192134.1  protein lin-9 homolog isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TKA1.1 GenPept UniProtKB/Swiss-Prot:Q5TKA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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