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    GPX7 glutathione peroxidase 7 [ Homo sapiens (human) ]

    Gene ID: 2882, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPX7provided by HGNC
    Official Full Name
    glutathione peroxidase 7provided by HGNC
    Primary source
    HGNC:HGNC:4559
    See related
    Ensembl:ENSG00000116157 MIM:615784; AllianceGenome:HGNC:4559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPX6; CL683; GPx-7; NPGPx; GSHPx-7
    Summary
    Enables catalase activity. Predicted to be involved in cellular response to oxidative stress. Located in endoplasmic reticulum. Implicated in Barrett's adenocarcinoma and Barrett's esophagus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 9.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPX7 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52602371..52609051)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52483604..52490521)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53068043..53074723)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53036969-53037469 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene uncharacterized LOC124904178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1035 Neighboring gene shisa like 2A Neighboring gene Sharpr-MPRA regulatory region 2435 Neighboring gene Sharpr-MPRA regulatory region 753 Neighboring gene Sharpr-MPRA regulatory region 13275 Neighboring gene MPRA-validated peak230 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 897 Neighboring gene cytochrome c oxidase assembly factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis. Chen B, et al. Mol Med Rep, 2024 Jul. PMID 38757339, Free PMC Article
    2. Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas. Ferreira WAS, et al. Sci Rep, 2022 Apr 19. PMID 35440701, Free PMC Article
    3. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Peng D, et al. Gut, 2014 Apr. PMID 23580780, Free PMC Article
    4. MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis. Hanousková B, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Oct. PMID 34339889
    5. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. Utomo A, et al. J Biol Chem, 2004 Oct 15. PMID 15294905

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL-1beta, via a mechanism mediated by ferroptosis.
      Title: GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
    2. Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.
      Title: Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.
    3. GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.
      Title: GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.
    4. MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.
      Title: MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.
    5. Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
      Title: Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
    6. use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.
      Title: GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.
    7. SNPs most associated with Chemotherapy-induced peripheral neuropathy were in ATP-binding cassette sub-family C member 4 (ABCC4) gene.
      Title: Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.
    8. Loss of glutathione peroxidase 7 promotes TNF-alpha-induced NF-kappaB activation in Barrett's carcinogenesis.
      Title: Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis.
    9. GPx7 promotes oxidative protein folding, directly utilizing Ero1alpha-generated hydrogen peroxide in the early secretory compartment.
      Title: Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding.
    10. tumour suppressor functions in esophageal adenocarcinomas and silenced by location-specific promoter DNA methylation
      Title: Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed
    Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
    tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables catalase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione peroxidase 7
    Names
    glutathione peroxidase 6
    non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
    NP_056511.2
    XP_047274516.1
    XP_047274520.1
    XP_054192135.1
    XP_054192136.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015696.5 → NP_056511.2  glutathione peroxidase 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AK027683, BI550170, BU627166
      Consensus CDS
      CCDS569.1
      UniProtKB/Swiss-Prot
      O95337, Q5T501, Q96SL4
      Related
      ENSP00000354677.4, ENST00000361314.5
      Conserved Domains (1) summary
      TIGR02540
      Location:24 → 176
      gpx7; putative glutathione peroxidase Gpx7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52602371..52609051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418560.1 → XP_047274516.1  glutathione peroxidase 7 isoform X1

    2. XM_047418564.1 → XP_047274520.1  glutathione peroxidase 7 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52483604..52490521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336160.1 → XP_054192135.1  glutathione peroxidase 7 isoform X1

    2. XM_054336161.1 → XP_054192136.1  glutathione peroxidase 7 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96SL4.1 GenPept UniProtKB/Swiss-Prot:Q96SL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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