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    Upp1 uridine phosphorylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289801, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Upp1provided by RGD
    Official Full Name
    uridine phosphorylase 1provided by RGD
    Primary source
    RGD:1305566
    See related
    EnsemblRapid:ENSRNOG00000004972 AllianceGenome:RGD:1305566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and pyrimidine-nucleoside phosphorylase activity. Involved in cellular response to glucose starvation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of middle cerebral artery infarction. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 123.5), Heart (RPKM 80.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Upp1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (88023155..88043036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (83809495..83829299)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (89314234..89334060)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HUS1 checkpoint clamp component Neighboring gene similar to human chromosome 7 open reading frame 57 Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 48 Neighboring gene ATP binding cassette subfamily A member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Active site conformational dynamics in human uridine phosphorylase 1. Roosild TP, et al. PLoS One, 2010 Sep 14. PMID 20856879, Free PMC Article
    2. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. Roosild TP, et al. BMC Struct Biol, 2009 Mar 16. PMID 19291308, Free PMC Article
    3. Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase. Choi JW, et al. J Neurotrauma, 2008 Jun. PMID 18457515
    4. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. Cao D, et al. J Biol Chem, 2005 Jun 3. PMID 15772079
    5. Purification, cloning, and expression of murine uridine phosphorylase. Watanabe S, et al. J Biol Chem, 1995 May 19. PMID 7744869

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124655

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deoxyuridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables thymidine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thymidine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uridine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uridine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within uridine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uridine phosphorylase 1
    NP_001025196.1
    XP_006251545.1
    XP_006251546.1
    XP_006251547.1
    XP_006251549.1
    XP_038947688.1
    XP_038947690.1
    XP_038947691.1
    XP_038947692.1
    XP_063129045.1
    XP_063129046.1
    XP_063129047.1
    XP_063129048.1
    XP_063129049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030025.2 → NP_001025196.1  uridine phosphorylase 1

      See identical proteins and their annotated locations for NP_001025196.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      88023155..88043036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251484.5 → XP_006251546.1  uridine phosphorylase 1 isoform X1

      See identical proteins and their annotated locations for XP_006251546.1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    2. XM_039091760.2 → XP_038947688.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    3. XM_006251483.4 → XP_006251545.1  uridine phosphorylase 1 isoform X1

      See identical proteins and their annotated locations for XP_006251545.1

      UniProtKB/TrEMBL
      Q499V1
      Related
      ENSRNOP00000006765.6, ENSRNOT00000006765.9
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    4. XM_063272978.1 → XP_063129048.1  uridine phosphorylase 1 isoform X2

      UniProtKB/TrEMBL
      F7F0D5

    5. XM_063272977.1 → XP_063129047.1  uridine phosphorylase 1 isoform X2

      UniProtKB/TrEMBL
      F7F0D5

    6. XM_039091762.2 → XP_038947690.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    7. XM_039091764.2 → XP_038947692.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    8. XM_006251485.5 → XP_006251547.1  uridine phosphorylase 1 isoform X1

      See identical proteins and their annotated locations for XP_006251547.1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    9. XM_006251487.4 → XP_006251549.1  uridine phosphorylase 1 isoform X2

      UniProtKB/TrEMBL
      F7F0D5
      Conserved Domains (1) summary
      cd17763
      Location:32 → 306
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    10. XM_039091763.2 → XP_038947691.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1
      Conserved Domains (1) summary
      cd17763
      Location:33 → 307
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    11. XM_063272975.1 → XP_063129045.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1

    12. XM_063272979.1 → XP_063129049.1  uridine phosphorylase 1 isoform X2

      UniProtKB/TrEMBL
      F7F0D5

    13. XM_063272976.1 → XP_063129046.1  uridine phosphorylase 1 isoform X1

      UniProtKB/TrEMBL
      Q499V1
    Nucleotide Protein Strain
    Heading Accession and Version

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