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    FAM156A family with sequence similarity 156 member A [ Homo sapiens (human) ]

    Gene ID: 29057, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FAM156Aprovided by HGNC
    Official Full Name
    family with sequence similarity 156 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:30114
    See related
    Ensembl:ENSG00000268350 AllianceGenome:HGNC:30114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM29; PRO0659
    Summary
    Predicted to enable methylated histone binding activity. Located in nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 15.8), placenta (RPKM 14.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FAM156A in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52947254..52995472, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52231792..52279984, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52976462..53024651, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member B Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52949629-52950232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29647 Neighboring gene uncharacterized LOC124905190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29649 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52963212-52964184 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52964185-52965156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene G protein-coupled receptor 173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene TSPY like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
    3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
    4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
    5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686B22211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM156A/FAM156B
    Names
    protein FAM156A
    transmembrane protein 29
    transmembrane protein 29/29B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242489.2 → NP_001229418.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      AK057692, BC000867, DA685609, DA849151
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000479184.1, ENST00000615092.4
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    2. NM_001242490.2 → NP_001229419.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, BU192418, DA347198, DA572135
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000477905.2, ENST00000622323.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    3. NM_001242491.1 → NP_001229420.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      AK057692, BC000867, DA371625
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000481435.1, ENST00000617970.4
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    4. NM_001242492.2 → NP_001229421.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, BC067819, BI829697, DA685609
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000485247.1, ENST00000623782.3
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    5. NM_001242493.2 → NP_001229422.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, DA347198, DA572135, DA691898
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000484967.2, ENST00000612083.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    6. NM_001242494.2 → NP_001229423.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, DA347198, DA685609
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    7. NM_001242495.2 → NP_001229424.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, BC067819, DA685609
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000480518.1, ENST00000611661.4
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    8. NM_001242496.2 → NP_001229425.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      BC000867, BC067819, CB139342, DA572135
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000484757.2, ENST00000619373.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    9. NM_001242497.2 → NP_001229426.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 encode the same protein.
      Source sequence(s)
      AF090943, DA368012, DA572135
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000479338.2, ENST00000622732.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    10. NM_001377060.1 → NP_001363989.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000471676.1, ENST00000596733.7
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    11. NM_001377061.1 → NP_001363990.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000482562.2, ENST00000619518.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    12. NM_001377062.1 → NP_001363991.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    13. NM_001377063.1 → NP_001363992.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000480373.1, ENST00000613284.1
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    14. NM_001387706.1 → NP_001374635.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000482142.1, ENST00000622447.5
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    15. NM_014138.5 → NP_054857.2  protein FAM156A/FAM156B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 encode the same protein.
      Source sequence(s)
      AK057692, BC000867, DA256347, DA572135
      Consensus CDS
      CCDS35297.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000484167.1, ENST00000612915.4
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      52947254..52995472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029457.1 → XP_016884946.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    2. XM_047442036.1 → XP_047297992.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    3. XM_047442034.1 → XP_047297990.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      Related
      ENSP00000482980.2, ENST00000618601.5

    4. XM_047442033.1 → XP_047297989.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      Related
      ENSP00000479348.2, ENST00000612846.5

    5. XM_047442037.1 → XP_047297993.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    6. XM_047442032.1 → XP_047297988.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      Related
      ENSP00000479822.2, ENST00000619586.5

    7. XM_047442035.1 → XP_047297991.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52231792..52279984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326919.1 → XP_054182894.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    2. XM_054326916.1 → XP_054182891.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    3. XM_054326917.1 → XP_054182892.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    4. XM_054326915.1 → XP_054182890.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    5. XM_054326920.1 → XP_054182895.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    6. XM_054326914.1 → XP_054182889.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    7. XM_054326918.1 → XP_054182893.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDB6.1 GenPept UniProtKB/Swiss-Prot:Q8NDB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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