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    Nfic nuclear factor I/C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29228, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nficprovided by RGD
    Official Full Name
    nuclear factor I/Cprovided by RGD
    Primary source
    RGD:62016
    See related
    EnsemblRapid:ENSRNOG00000004505 AllianceGenome:RGD:62016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 108.3), Heart (RPKM 61.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nfic in Genome Data Viewer
    Location:
    7q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8928423..8963455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8278210..8309936)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11151941..11179544)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nicalin Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene uncharacterized LOC120093769 Neighboring gene small integral membrane protein 24 Neighboring gene small integral membrane protein 44

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nuclear factor 1 C-type
    Names
    olfactory epithelium nuclear factor I-C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031567.1NP_113755.1  nuclear factor 1 C-type

      See identical proteins and their annotated locations for NP_113755.1

      Status: PROVISIONAL

      Source sequence(s)
      AB012233
      UniProtKB/TrEMBL
      A0A8I5ZTI5, O70188
      Related
      ENSRNOP00000006168.6, ENSRNOT00000006168.9
      Conserved Domains (3) summary
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:217424
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68169
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8928423..8963455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078560.2XP_038934488.1  nuclear factor 1 C-type isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYT8, A0A8I6AMP4
      Related
      ENSRNOP00000077960.2, ENSRNOT00000093863.2
      Conserved Domains (3) summary
      pfam10524
      Location:83119
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:289496
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:140241
      MH1; N-terminal Mad Homology 1 (MH1) domain
    2. XM_039078561.2XP_038934489.1  nuclear factor 1 C-type isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTI5
      Related
      ENSRNOP00000090255.2, ENSRNOT00000103665.2
      Conserved Domains (3) summary
      pfam10524
      Location:83119
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:289495
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:140241
      MH1; N-terminal Mad Homology 1 (MH1) domain
    3. XM_006240850.5XP_006240912.1  nuclear factor 1 C-type isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTI5, A0A8I5ZZR6
      Related
      ENSRNOP00000083709.2, ENSRNOT00000097025.2
      Conserved Domains (3) summary
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:217423
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68169
      MH1; N-terminal Mad Homology 1 (MH1) domain