Slc39a7 solute carrier family 39 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc39a7provided by RGD
Official Full Name: solute carrier family 39 member 7provided by RGD
Primary source: RGD:1593280
See related: EnsemblRapid:ENSRNOG00000000465 AllianceGenome:RGD:1593280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ke4; ZIP7; Rt1Ke4; RT1-Ke4
Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including intracellular zinc ion homeostasis; regulation of ferroptosis; and zinc ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and nucleoplasm. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 280.8), Liver (RPKM 241.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4824967..4828431)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4823166..4826538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3819416..3822788, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and sarco(endo)plasmic reticulum and contribute to cellular Zn(2+)-muffling between cellular-compartments in hyperglycemia or hypertrophic cardiomyocytes via affecting sarco(endo)plasmic reticulum-mitochondria coupling.
Title: Zn(2+)-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.
Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular cardiomyocytes from diabetic rats or high-glucose-treated H9c2 cells while ZnT7 expression was low. ZIP7 phosphorylation was increased in response to high glucose in vivo and in vitro.
Title: Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

Submit: New GeneRIF Correction

General gene information

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Markers

BM385817 (e-PCR)
- UniSTS:261386

Slc39a7 (e-PCR), detects polymorphism
- UniSTS:463430

RH129332 (e-PCR)
- UniSTS:212639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ferroptosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin epidermis development	ISO Inferred from Sequence Orthology more info
involved_in skin epidermis development	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter SLC39A7

Names: Histidine-rich membrane protein; RT1 class I, locus Ke4; RT1 region expressed gene KE4; solute carrier family 39 (zinc transporter), member 7; zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008885.2 → NP_001008885.1 zinc transporter SLC39A7 precursor

See identical proteins and their annotated locations for NP_001008885.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC079141

UniProtKB/Swiss-Prot

F7EQL7, Q6MGB4

UniProtKB/TrEMBL

A0A9M1WLR8

Conserved Domains (1) summary

pfam02535
Location:126 → 445

Zip; ZIP Zinc transporter
NM_001164744.1 → NP_001158216.1 zinc transporter SLC39A7 precursor

See identical proteins and their annotated locations for NP_001158216.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC079141, DY547565

UniProtKB/Swiss-Prot

F7EQL7, Q6MGB4

UniProtKB/TrEMBL

A0A9M1WLR8

Related

ENSRNOP00000000541.6, ENSRNOT00000000541.9

Conserved Domains (1) summary

pfam02535
Location:126 → 445

Zip; ZIP Zinc transporter